| Main Title |
Glutathione Peroxidase and Glutathione Transferase Activity in Rat Lung and Liver Following Cadmium Inhalation. |
| Author |
Grose, E. C. ;
Richards, J. H. ;
Jaskot, R. H. ;
Menache, M. G. ;
Graham, J. A. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group. ;North Carolina State Univ. at Raleigh. |
| Year Published |
1987 |
| Report Number |
EPA/600/J-87/088; |
| Stock Number |
PB88-125539 |
| Additional Subjects |
Toxicology ;
Cadmium ;
Enzyme inhibitors ;
Respiration ;
Exposure ;
Lung ;
Liver ;
Laboratory animals ;
Rats ;
Toxicity ;
Reprints ;
Glutathione peroxidase ;
Glutathione transferases ;
Toxic substances
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB88-125539 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
A 2 hr inhalation exposure to 4.6 mg Cd/cu m decreased pulmonary total glutathione peroxidase (GSH Px) activity and non-selenium peroxidase (GSH non-Se-Px) activity but had no effect on GSH selenium peroxidase (Se-Px) activity. Seventy-two hrs after exposure there was an increase in total GSH Px and GSH Se-Px activity. Exposure to 0.44 mg Cd/cu m for 2 hr caused no effect on GSH Se-Px at either 0 or 72 hr post exposure, but total GSH Px and GSH non-Se-Px activities were decreased up to 72 hr post exposure. Exposure to 4.6 mg Cd/cu m caused an increase in hepatic GSH Se-Px activity 72 hr post exposure, but no other significant changes were observed in the liver. Changes in GSH non-Se-Px activity did not relate to changes in GSH transferase (Tr) activity. The data suggest that alterations in GSH Px activity by Cd(+2) may be due to changes in GSH non-Se-Px activity and that changes in pulmonary GSH Tr and GSH non-Se-Px activities may not be as closely linked as in the liver. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.) |
| Supplementary Notes |
Pub. in Toxicology, v44 p171-179 1987. Prepared in cooperation with Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group, and North Carolina State Univ. at Raleigh. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Glutathione Peroxidase and Glutathione Transferase Activity in Rat Lung and Liver Following Cadmium Inhalation. |
| PUB Date Free Form |
c1987 |
| Category Codes |
57Y; 57S |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
802920006 |
| Origin |
NTIS |
| Type |
CAT |
