||Glutathione Peroxidase and Glutathione Transferase Activity in Rat Lung and Liver Following Cadmium Inhalation.
Grose, E. C. ;
Richards, J. H. ;
Jaskot, R. H. ;
Menache, M. G. ;
Graham, J. A. ;
||Health Effects Research Lab., Research Triangle Park, NC. ;Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group. ;North Carolina State Univ. at Raleigh.
Enzyme inhibitors ;
Laboratory animals ;
Glutathione peroxidase ;
Glutathione transferases ;
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||A 2 hr inhalation exposure to 4.6 mg Cd/cu m decreased pulmonary total glutathione peroxidase (GSH Px) activity and non-selenium peroxidase (GSH non-Se-Px) activity but had no effect on GSH selenium peroxidase (Se-Px) activity. Seventy-two hrs after exposure there was an increase in total GSH Px and GSH Se-Px activity. Exposure to 0.44 mg Cd/cu m for 2 hr caused no effect on GSH Se-Px at either 0 or 72 hr post exposure, but total GSH Px and GSH non-Se-Px activities were decreased up to 72 hr post exposure. Exposure to 4.6 mg Cd/cu m caused an increase in hepatic GSH Se-Px activity 72 hr post exposure, but no other significant changes were observed in the liver. Changes in GSH non-Se-Px activity did not relate to changes in GSH transferase (Tr) activity. The data suggest that alterations in GSH Px activity by Cd(+2) may be due to changes in GSH non-Se-Px activity and that changes in pulmonary GSH Tr and GSH non-Se-Px activities may not be as closely linked as in the liver. (Copyright (c) 1987 Elsevier Scientific Publishers Ireland Ltd.)
||Pub. in Toxicology, v44 p171-179 1987. Prepared in cooperation with Northrop Services, Inc., Durham, NC. Inhalation Toxicology Group, and North Carolina State Univ. at Raleigh.
|NTIS Title Notes
||Reprint: Glutathione Peroxidase and Glutathione Transferase Activity in Rat Lung and Liver Following Cadmium Inhalation.
|PUB Date Free Form
||PC A03/MF A01