||Effects of Epichlorohydrin on Male and Female Reproduction in Long-Evans Rats.
Toth, G. P. ;
Zenick, H. ;
Smith, M. K. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Body weight ;
Germ cells ;
Animal physiology ;
Dose-response relationships ;
Animal sex behavior ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Male and female Long-Evans rats were treated with epichlorohydrin (ECH) by oral gavage (males: 12.5, 25, and 50 mg/kg/day; females: 25, 50, and 100 mg/kg/day) for 21 and 14 days respectively, prior to mating trials with untreated animals. Treated females were further dosed until delivery. Infertility was induced in males at 50 mg ECH/kg/day, while no measured parameters of female reproduction were changed relative to controls. Treated males showed normal copulatory behavior. Sperm morphology and percent motile sperm were not statistically different from control values in both ejaculated and cauda epididymal samples from ECH-treated animals. The number of sperm in ejaculates was normal while cauda epididymal sperm count was slightly decreased in males at the 50 mg ECH/kg dose level. Mean curvilinear velocity, straight-line velocity, and the amplitude of lateral head displacement of cauda epididymal sperm were significantly reduced by ECH at 12.5 mg/kg/day. Sperm track linearity was also reduced, but only at 50 mg/kg/day. Beat/cross frequency of sperm was significantly increased at 12.5 mg/kg/day. (Copyright (c) 1989 The Society of Toxicology.)
||Pub. in Fundamental and Applied Toxicology, v13 p16-25 1989.
|NTIS Title Notes
||Reprint: Effects of Epichlorohydrin on Male and Female Reproduction in Long-Evans Rats.
||PC A03/MF A01