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RECORD NUMBER: 11 OF 47

OLS Field Name OLS Field Data
Main Title Dimethyltin Dichloride: Investigations into Its Gastrointestinal Absorption and Transplacental Transfer.
Author Noland, E. A. ; McCauley, P. T. ; Bull, R. J. ;
CORP Author Health Effects Research Lab., Cincinnati, OH.
Year Published 1983
Report Number EPA-600/J-83-220;
Stock Number PB84-213149
Additional Subjects Toxicology ; Rats ; Laboratory animals ; Absorption ; Gastrointestinal system ; Reprints ; Dimethyltin dichloride ; DMDC ; Water pollution effects(Animals)
Holdings
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Status
NTIS  PB84-213149 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 12p
Abstract Dimethyltin dichloride (DMDC) is commonly used as a stabilizer in PVC pipe used for transport of potable water. Learning deficiencies have been observed postnatally in pups from DMDC-treated dams. Studies were conducted with female Sprague-Dawley rats to determine whether DMDC was absorbed by the dam and transferred across the placenta to fetal blood and brain tissue. This was accomplished in three phases: (1) a comparison of absorption of organic and inorganic tin from drinking water, (2) a comparison of prenatal and postnatal levels of tin in the pups in cross-fostering studies, and (3) a (14C)dimethyltin dichloride tracer study to determine whether organic tin passed to the pup intact. Major findings include: (1) DMDC is absorbed in the gastrointestinal tract of the dam much more rapidly than Sn2+; (2) the more rapid absorption of DMDC results in higher concentration of tin in fetal blood and brain; and (3) in fetuses that receive tin as DMDC, both tin and the methyl carbon are absorbed by the dam and transferred to the blood and brain of the fetuses.
Supplementary Notes Pub. in Toxicology and Environmental Health 12, p89-98 1983.
NTIS Title Notes Journal article.
Title Annotations Reprint: Dimethyltin Dichloride: Investigations into Its Gastrointestinal Absorption and Transplacental Transfer.
PUB Date Free Form 1983
Category Codes 6T; 6F; 57Y; 68F
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 427225120
Origin NTIS
Type CAT