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RECORD NUMBER: 294 OF 316| Main Title | Studies of the Inhalation Toxicity of Formaldehyde. | |||||||||||
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| CORP Author | ; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Year Published | 1985 | |||||||||||
| Report Number | 60-00022057 | |||||||||||
| Stock Number | OTS0525012 | |||||||||||
| Additional Subjects | Toxicology ; Health effects ; Formaldehyde ; Acute Toxicity ; Mammals ; Rats ; Inhalation ; Chronic Toxicity ; Combined Chronic Toxicity/carcinogenicity ; Toxic substances ; Laboratory animals ; CAS No 50-00-0 | |||||||||||
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| Collation | 77p | |||||||||||
| Abstract | The acute inhalation toxicity of formaldehyde was tested in male Wistar rats (3/group) exposed to 0, 10, 20, or 30 ppm for 6 hours. No effects were noted in the 10 ppm animals, but in the 2- and 30 ppm groups, sniffing and face-washing movements were seen, along with yellowing of the abdominal hair ( around the penis), decreased plasma alkaline phosphatase activity and increased lung alkaline phosphatase activity, decreased white blood cell counts (high-dose group), congestion of the nasal and tracheal mucous membranes, and hemorrhagic foci in the lungs. Exposure of male Fisher rats (32/group) to 0, 0.3, 2.0, or 15.0 ppm for 6 hours/day 5 days/week, for 28 months led to decreased weight gain and good intake, runny noses, lacrimation, crouching, yellowing of the abdominal hair, bleeding from forelimbs, and death of 20/32 rats in the high-dose group. Squamous cell carcinoma (14/32) and papilloma (5/32) were seen in high-dose rats, but no neoplastic changes were noted in the 0, 0.3 or 2.0 ppm groups. Dose-related excessive secretion, rhinitis, desquamation, squamous epithelial metaplasia and epithelial cell hyperplasia were observed, beginning in the low-dose group. | |||||||||||
| Supplementary Notes | The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. | |||||||||||
| Availability Notes | Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. | |||||||||||
| PUB Date Free Form | 1985 | |||||||||||
| Category Codes | 57Y; 57U; 68G; 99; 44G | |||||||||||
| NTIS Prices | PC A06/MF A06 | |||||||||||
| Document Type | NT | |||||||||||
| Cataloging Source | NTIS/MT | |||||||||||
| Control Number | 028802550 | |||||||||||
| Origin | NTIS | |||||||||||
| Type | CAT |