Main Title |
Utility of the Murine Erythroleukemic Cell (MELC) in Assessing Mechanisms of Action of DNA-Active Developmental Toxicants: Application to 5-Fluorouracil. |
Author |
Elstein, K. H. ;
Zucker, R. M. ;
Shuey, D. L. ;
Lau, C. ;
Chernoff, N. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
Publisher |
1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/386; |
Stock Number |
PB93-236651 |
Additional Subjects |
Erythroleukemia ;
Fluorouracil ;
Toxicology ;
Deoxyribonucleic acids ;
Teratogenic compounds ;
Mice ;
S phase ;
Antineoplastic agents ;
Thymidylate synthetase ;
Flow cytometry ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-236651 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
15p |
Abstract |
Murine erythroleukemic cells (MELC) exposed to 2'-deoxy-5-azacytidine (D-AZA) or to the active cyclophosphamide (CP) metabolites phosphoramide mustard (PAM) and 4-hydroxycyclophosphamide (OHCP) exhibit cell-cycle perturbations similar to those seen in limb bud nuclei of gestational day (GD) 10 CD-1 mouse embryos exposed in utero to D-AZA or CP, respectively. The similarities in response suggest MELC may be a useful model for determining mechanisms of action of DNA-active developmental toxicants. (Copyright (c) 1993 Wiley-Liss, Inc.) |
Supplementary Notes |
Pub. in Teratology, v48 n1 p75-87 Jul 93. See also PB92-206283. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Utility of the Murine Erythroleukemic Cell (MELC) in Assessing Mechanisms of Action of DNA-Active Developmental Toxicants: Application to 5-Fluorouracil. |
Category Codes |
57Y; 57F |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
330926048 |
Origin |
NTIS |
Type |
CAT |