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RECORD NUMBER: 2 OF 2

OLS Field Name OLS Field Data
Main Title Screening methods for toxic substances /
Author Sikka, Harish Chandra.
CORP Author Syracuse Research Corp., N.Y.;Health Effects Research Lab., Research Triangle Park, N.C. Environmental Toxicology Div.
Publisher U.S. Environmental Protection Agency, Health Effects Research Laboratory ,
Year Published 1978
Report Number EPA-600/1-78-014; EPA-68-02-1786
Stock Number PB-277 017
OCLC Number 42843379
Subjects Toxicity testing. ; Neurotoxic agents. ; Phenytoin--Toxicology. ; DDT (Insecticide)--Toxicology. ; Neurotoxic agents--Screening
Additional Subjects Brain ; Neurology ; Toxicology ; DDT ; Pesticides ; Synapses ; Nervous system ; Nerve cells ; Membranes ; Permeability ; Ions ; Pathology ; Detection ; Toxicity ; Tests ; Sublethal dosage ; Rats ; Laboratory animals ; In vitro analysis ; Toxic substances ; Synaptosomes ; Fluorescent probes
Internet Access
Description Access URL
http://nepis.epa.gov/Exe/ZyPDF.cgi?Dockey=91013W4H.PDF
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
EJAD  EPA 600/1-78-014 Region 3 Library/Philadelphia, PA 01/14/2000
EJBD ARCHIVE EPA 600-1-78-014 Headquarters Library/Washington,DC 05/27/2014
EJBD  EPA 600-1-78-014 c.1 Headquarters Library/Washington,DC 06/09/2014
EJED  EPA 600/1-78/014 OCSPP Chemical Library/Washington,DC 01/13/2001
EKAM  EPA 600/1-78/014 Region 4 Library/Atlanta,GA 11/19/1999
EKBD  EPA-600/1-78-014 Research Triangle Park Library/RTP, NC 02/23/2000
ELDD  EPA 600/1-78/014 NHEERL/MED Library/Duluth,MN 09/08/2000
NTIS  PB-277 017 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/23/1988
Collation v, 18 p. ; 28 cm.
Abstract The present report deals with the application of fluorescent probe technique to the detection of conformational changes in rat brain synaptosomes under the influence of certain neurotoxic chemicals, chlorophenothane (DDT) and diphenylhydantoin, which are expected to produce functional changes in nerve membranes. Pretreatment of the rats with (1) a single dose of DDT capable of producing neurological symptoms and (2) repeated sub-lethal doses of DDT did not alter the fluorescence characteristics of the hydrophobic probe 8-anilino-1-naphthalene sulfonic acid (ANS) bound to the synaptosomes. DDT treatment also showed no effect on native protein fluorescence of synaptosomes. Exposure of synaptosomes to diphenylhydantoint in vitro did not induce conformational changes as measured by ANS and intrinsic fluorescence.
Notes "EPA-600/1-78-014". EPA contract no. 68021786; EPA project officer: Larry L. Hall. Includes bibliographical references (p. 16-17).
Place Published Research Triangle Park, NC
Access Notes Also available via the World Wide Web.
Corporate Au Added Ent Health Effects Research Laboratory (Research Triangle Park, N.C.); United States. Environmental Protection Agency. Office of Research and Development.; Syracuse Research Corporation.
Title Ser Add Ent Research reporting series. Environmental health effects research ; EPA 600/1-78/014.
PUB Date Free Form February 1978
Series Title Untraced Environmental health effects research series ; EPA 600/1-78/014
Category Codes 6T; 6A; 57Y; 57B
NTIS Prices PC A03/MF A01
Primary Description 600/11
BIB Level m
Cataloging Source OCLC/T
Control Number 323733073
OCLC Time Stamp 20140604154033
Language eng
Origin OCLC
Type MERGE
OCLC Rec Leader 01524cam 2200361Ka 45020