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OLS Field Name OLS Field Data
Main Title Formation of DNA Adducts in 1OT1/2 Mouse Embryo Fibroblasts Incubated with Benzo(a)pyrene or Dihydrodiol Oxide Derivatives.
Author Brown, Halina Szejnwald ; Jeffrey, Alan M. ; Weinstein, I. Bernard ;
CORP Author Columbia Univ., New York.;Health Effects Research Lab., Research Triangle Park, NC.;National Cancer Inst., Bethesda, MD.
Year Published 1979
Report Number EPA-R-805482 ;PHS-CA-13696; EPA-600/J-79-148;
Stock Number PB83-145292
Additional Subjects Deoxyribonucleic acid ; Aromatic polycyclic hydrocarbons ; Binding ; Mice ; Embryos ; Oxygen organic compounds ; Stereochemistry ; Reprints ; Dihydrodiol oxide ; Metabolites ; Cell lines ; Benzopyrenes ; Fibroblasts
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NTIS  PB83-145292 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 7p
Abstract Binding of benzo(a)pyrene (BP) metabolites to DNA was studied in the mouse embryo fibroblast 10T one half cell line. The cells metabolized BP to its diastereoisomeric 7,8-dihydrodiol-9,10-oxides, (+)-7B, 8a-dihydroxy-9B, 10B-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene, which formed covalent adducts with cellular DNA. Detailed analysis by high-pressure liquid chromatography indicated that a deoxyguanosine adduct, N2-(10S-(7R, 8S, 9R-trihydroxy-7,8,9,10-tetrahydrobenzo(a)pyrene)yldeoxyguaninosine, was the predominant DNA adduct formed in cells exposed to BP. This adduct is also the major one found in human tissues exposed to BP.
Supplementary Notes Pub. in Cancer Research 39, p1673-1677 May 79.
NTIS Title Notes Journal article.
Title Annotations Reprint: Formation of DNA Adducts in 1OT1/2 Mouse Embryo Fibroblasts Incubated with Benzo(a)pyrene or Dihydrodiol Oxide Derivatives.
PUB Date Free Form 30 Jan 79
Category Codes 6A; 57B
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 305048128
Origin NTIS
Type CAT