Main Title |
Statistical Problems (and Some Solutions) Associated with Testing for Effects in Developmental Toxicology. |
Author |
Setzer, R. W. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. |
Publisher |
1991 |
Year Published |
1991 |
Report Number |
EPA/600/D-91/224; |
Stock Number |
PB91-242453 |
Additional Subjects |
Teratogenic compounds ;
Toxicology ;
Fetus ;
Multivariate analysis ;
Statistical analysis ;
Laboratory animals ;
Litter effect
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-242453 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
18p |
Abstract |
Data from developmental toxicology present several problems from the standpoint of statistical testing. The concurrence of the litter effect (the correlation of responses of littermates), the large number of endpoints to be evaluated, and the fact that most developmental toxicology endpoints are quantal raises the need for unique statistical solutions for hypothesis testing. The paper reviews methods that have been developed to accomodate these problems, particularly those having to do with the litter effect, compares them with respect to power, and speculates on the structure of models that may incorporate more biological information about the nature of the litter effect. |
Supplementary Notes |
Presented at the symposium Risk Assessment of Prenatally-Induced Adverse Health Effects, Berlin, Germany, May 21-23, 1991. |
Category Codes |
57Y |
NTIS Prices |
PC A03/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
131121631 |
Origin |
NTIS |
Type |
CAT |