| Main Title |
Initial Submission: a Developmental Toxicity Study with Aminomethylphosphonic Acid in Rats (Final Report) with Cover Letter dated 07/10/92. |
| CORP Author |
Monsanto Co., Alvin, TX.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920004838 |
| Stock Number |
OTS0540915 |
| Additional Subjects |
Toxicology ;
Health effects ;
Aminomethylphosphonic Acid ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rats ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 1066-51-9
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0540915 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
266p |
| Abstract |
Aminomethylphosphonic acid (CAS No. 1066-51-9) was evaluated for developmental effects in groups of 25 female Charles River rats administered the test substance by gavage at dose levels of 0, 150, 400, or 1000 mg/kg/day in a constant dose volume of 10 mL/kg in corn oil on days 6 through 15 of gestation. Animals were sacrificed on day 20 of gestation. Clinical signs of toxicity at 400 and 1000 mg/kg/day included mucoid feces, hair loss and soft stool. Mean body weight gain was slightly reduced during days 12 through 16 of gestation at 1000 mg/kg/day (p<0.05). The 1000 mg/kg/day group showed slightly decreased mean fetal body weight. No treatment related fetal malformations or developmental variations were observed at any of the dose levels. The NOAEL was 150 mg/kg/day. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Sponsored by Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A13/MF A13 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803540 |
| Origin |
NTIS |
| Type |
CAT |
