Main Title |
Effect of 2-chlorotoluene Vapour on Pregnancy of the New Zealand White Rabbit with Cover Letter dated 08/19/1983. |
CORP Author |
Huntingdon Research Center, New City, NY.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
Year Published |
1983 |
Report Number |
40-8335094 |
Stock Number |
OTS0507457 |
Additional Subjects |
Toxicology ;
Health effects ;
2-chlorotoluene ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Rabbits ;
Inhalation ;
Subchronic Toxicity ;
Toxic substances ;
Laboratory animals ;
CAS No 95-49-8
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Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
OTS0507457 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
81p |
Abstract |
2-Chlorotoluene was tested for developmental toxicity in groups of 16 bred female New Zealand white rabbits receiving whole body exposure to nominal vapor concentrations of 0, 1.5, 4, and 10 mg/L for 6 hours/day on gestation days 6-28. At 10 mg/L, lacrimation, salivation, and ptosis was observed during initial exposures. At 4 and 10 mg/L, there was a significant dose-related reduction in food consumption during the treatment period, which resulted in retardation of mean weight gain between the onset of treatment and day 9 of gestation. The treatment had no significant effect on litter size, pre- and post implantation loss, litteror fetal weight, or incidence of skeletal anomalies and variants. |
Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Occidental Chemical Corp., Grand Island, NY. |
Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
PUB Date Free Form |
1983 |
Category Codes |
57Y; 57U; 68G; 99; 44G |
NTIS Prices |
PC A06/MF A06 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
028801200 |
Origin |
NTIS |
Type |
CAT |