| Main Title |
Initial Submission: Teratogenicity Study with N-butyl Acrylate in Mice with Cover Letter dated 07/22/92. |
| CORP Author |
Research Triangle Inst., Research Triangle Park, NC.; Rohm and Haas Co., Philadelphia, PA.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances. |
| Year Published |
1992 |
| Report Number |
88-920005519 |
| Stock Number |
OTS0544773 |
| Additional Subjects |
Toxicology ;
Health effects ;
N-butyl Acrylate ;
Reproduction/fertility Effects ;
Teratogenicity ;
Mammals ;
Mice ;
Oral ;
Gavage ;
Toxic substances ;
Laboratory animals ;
CAS No 141-32-2
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
OTS0544773 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
63p |
| Abstract |
N-butyl acrylate (141-32-3) was evaluated for developmental toxicity. Days and duration of exposures were not reported. One of 30, 1/27, 1/29, 2/30, 2/30, and 25/25 pregnant mice (strain was not reported) died when treated with 1, 1.5, 2.0, 2.5, 3.0, and 4.0 g/kg/day of N-butyl acrylate respectively. Eighty-eight mice were present in the control group. Average weight gain during pregnancy was significantly (p<0.03) affected at 1.5 g/kg or above. The average fetal weight was significantly (p<0.001) reduced at 1.5 g/kg/day or above. A significant (p<0.02) increase in the percent of resorptions was observed at 2.5 g/kg/day or above. At 1 g/kg/day or above the average percent of malformed fetuses was significantly (p < 0.03) increased. Fused ribs were significantly (p < 0.01) increased at dosages of 1.5, 2.5, and 3.0 g/kg/day and fused arches were significantly (p < 0.02) increased at 2.5 g/kg/day or above. These 2 malformations, as well cleft palate, exencephaly and open eye, followed a significant (p < 0.01) trend as the dose level increased. White lesions in the left cardiac ventricle also showed a significant trend (p < 0.003) at 2.5 g/kg/day or above. No further information was provided regarding this study. |
| Supplementary Notes |
The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Rohm and Haas Co., Philadelphia, PA. |
| Availability Notes |
Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA. |
| PUB Date Free Form |
1992 |
| Category Codes |
57Y; 57U; 68G; 99; 44G |
| NTIS Prices |
PC A05/MF A05 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
028803640 |
| Origin |
NTIS |
| Type |
CAT |
