||Effect of 2-chlorotoluene Vapour on Pregnancy of the Rat with Cover Letter dated 08/31/1983.
||Huntingdon Research Center, New City, NY.; Occidental Chemical Corp., Grand Island, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Reproduction/fertility Effects ;
Subchronic Toxicity ;
Toxic substances ;
Laboratory animals ;
CAS No 95-49-8
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||2-Chlorotoluene was tested for developmental toxicity in groups of 25 bred Charles River CD rats receiving whole body exposure to nominal vapor concentrations of 0, 1, 3, and 9 mg/L, for 6 hours/day on days 6-19 inclusive of gestation. At 9 mg/L, all parent animals showed brown fur staining and slight to moderate ataxia, and some showed lacrimation and/or salivation during exposure. Food consumption and mean body weight gain were significantly reduced at 9 mg/L. At 9 mg/L, litter and fetal weight were significantly reduced. There was no significant effect upon litter size, or pre- or post implantation loss. In the high-dose group, skeletal ossification was reduced, providing an increased incidence of fetuses with sternal variants and contributing to a significant increase in fetuses with skeletal anomalies; the authors implied that these effects were directly related to the lower fetal weights observed in the high- dose group.
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||57Y; 57U; 68G; 99; 44G
||PC A06/MF A06