||Developmental Toxicity Study of Inhaled Methyl Tertiary Butyl Ether in New Zealand White Rabbits (Final Report) with Attachments and Cover Letter Dated 07/12/1989.
||Bushy Run Research Ctr; Mellon Inst.-Union Carbide Corp., Export, PA. Bushy Run Research Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Methyl-t-butyl Ether ;
Reproduction/fertility Effects ;
Toxic substances ;
Laboratory animals ;
CAS No 1634-04-4
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Methyl tertiary butyl ether was evaluated for developmental toxicity in groups of 15 bred female New Zealand white rabbits receiving whole-body exposure to nominal vapor concentrations of 0, 100, 4000, and 8000 ppm for 6 hours/day on days 6-18 of gestation. Maternal mortality was not observed and all does were sacrificed on gestation day 29. A statistically significant (p < 0.01) reduction in food consumption rates was observed at 8000 ppm. Gross necropsy revealed significantly (p < 0.05) increased liver weights at 8000 ppm. There were no differences between control and treatment groups with respect to the number of corpora lutea, early and late resorptions, non-viable fetuses, viable implantations, pre- or post-implantation losses, sex ratios, or fetal malformations (skeletal, external, or visceral).
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||57Y; 57U; 68G; 99; 44G
||PC A14/MF A14