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OLS Field Name OLS Field Data
Main Title Male Fertility Study of Sprague-dawley Rats Exposed by Inhalation Route to Acetone Cyanohydrin with Cover Letter dated 04/25/1986.
CORP Author Monsanto Environmental Sciences Center, St. Louis, MO.; Monsanto Chemical Co., Dayton, OH.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1986
Report Number 878216404
Stock Number OTS0510332
Additional Subjects Toxicology ; Health effects ; Acetone Cyanohydrin (75-86-5) ; Reproduction/fertility Effects ; Mammals ; Rats ; Inhalation ; Toxic substances ; Laboratory animals ; CAS No 75-86-5
Library Call Number Additional Info Location Last
NTIS  OTS0510332 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 03/10/2010
Collation 175p
Abstract Fertility was evaluated in groups male Sprague-Dawley rats (15/group) receiving whole body exposure to acetone cyanohydrin at nominal concentrations of 10, 30 or 60ppm in a dynamic air flow chamber, 6hrs/day, 5days/week for 69 days (48 exposure days). After 48 exposure days, males were mated to three untreated females, exposure continued until the day of the last mating opportunity (58 exposure days). Mated females were sacrificed at mid-term (gestation days 13-15). There was no effect of treatment for all males as indicated by mortality, mean body weights, clinical observations and necropsy observations. The number of live implants and pre- and postimplantation losses were comparable for all females mated with untreated and treated males.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Monsanto Chemical Co., Dayton, OH.
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PUB Date Free Form 1986
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A09/MF A09
Document Type NT
Cataloging Source NTIS/MT
Control Number 028801500
Origin NTIS
Type CAT