||Letter Submitting One Enclosed Teratology Study and One Enclosed Supplementary Study on Isopropanol.
||British Industrial Biological Research Association, Carshalton (England).; Chemical Manufacturers Association, Washington, DC.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Isopropanol (67-63-0) ;
Reproduction/fertility Effects ;
Toxic substances ;
Laboratory animals ;
CAS No 67-63-0
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Isopropanol (CAS No. 67-63-0) was tested for developmental toxicity. The test substance was administered orally in the drinking water at 0, 0.5, 1.25, and 2.5% to pregnant rats (20/group) on gestation days 6-16. The rats were sacrificed on day 20 for examination. Animals in the two highest dose groups had reduced food and water intake, and a decrease in body weight was noted in the 2.5% group. Mean litter weight decreased with increasing concentration, and there was a statistically significant decrease in mean fetal body weight in the two highest groups compared to controls. No evidence of teratogenicity was noted.
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|PUB Date Free Form
||57Y; 57U; 68G; 99; 44G
||PC A10/MF A10