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OLS Field Name OLS Field Data
Main Title Initial Submission: Teratology Study of Guar Gum in Rabbits with Attachments and Cover Letter dated 08/03/92.
CORP Author International Research and Development Corp., Mattawan, MI.; Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920004924
Stock Number OTS0542101
Additional Subjects Toxicology ; Health effects ; Guar Gum ; Reproduction/fertility effects ; Teratogenicity ; Mammals ; Rabbits ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 9000-30-0
Library Call Number Additional Info Location Last
NTIS  OTS0542101 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 150p
Abstract The developmental effects of guar gum (9000-30-0) were evaluated in groups of 20 rabbits by daily dermal administration of the test substance for 6 hours/day at dose levels of 0, 2, 10 and 50 mg/kg/day on days 6 through 18 of gestation. Surviving animals were sacrificed on day 29 of gestation. Mortalities included 2 deaths at 50 mg/kg/day and 1 death at 10 mg/kg/day. A single animal in the control group was sacrificed in extremis. A dose-related increase in dermal irritation (including erythema, edema, and desquamation) was observed in animals receiving 10 and 50 mg/kg/day. The number of early resorptions was significantly increased and the number of viable fetuses was correspondingly decreased at 50 mg/kg/day (p<0.05). The frequency of fetal malformations and variations in the treated groups was comparable to that of the control group at all dose levels. The NOEL was 2 mg/kg/day.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with Proctor and Gamble Co., Cincinnati, OH. Ivorydale Technical Center.
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PUB Date Free Form 1992
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A08/MF A08
Document Type NT
Cataloging Source NTIS/MT
Control Number 028803560
Origin NTIS
Type CAT