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OLS Field Name OLS Field Data
Main Title Initial Submission: Teratological Dose Range-finding Study with N-methylpyrrolidone in Sprague-dawley Rats (Final Report) with Attachments and Cover Letter Dated 02/27/1992.
CORP Author Food and Drug Research Labs., Inc., Waverly, NY.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Year Published 1992
Report Number 88-920001293
Stock Number OTS0535882
Additional Subjects Toxicology ; Health effects ; N-methylpyrrolidone ; Reproduction/fertility Effects ; Teratogenicity ; Mammals ; Rats ; Dermal ; Toxic substances ; Laboratory animals ; CAS No 872-50-4
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NTIS  OTS0535882 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/10/2010
Collation 69p
Abstract N-Methylpyrrolidone (872-50-4) was evaluated in a dose range-finding teratology study in which groups of 5 female Sprague-Dawley rats were administered the test substance dermally applied to the back at 0, 0.5, 1.1, or 2.5 g/kg/day on days 6 through 15 of gestation. Animals were sacrificed on da 20 of gestation. Animals in all test levels had dry patches of skin on the backs and showed bright yellow urine. Four out of 5 animals at the 2.5 g/kg/day group died. Maternal body weight gain was decreased at 1.1 g/kg/day but was not affected at 0.5 g/kg/day. At 1.1 g/kg/day 65/66 fetuses were resorbed (the single surviving fetus wassignificantly smaller than control fetuses). There was no effects on pregnancy, implantation, or gestation in the 0.5 g/kg/day group when compared with controls. None of the fetuses from treated dams at any level exhibited external abnormalities or malformations. Significance was judged at a probability level of 0.05 in all cases.
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PUB Date Free Form 1992
Category Codes 57Y; 57U; 68G; 99; 44G
NTIS Prices PC A05/MF A05
Document Type NT
Cataloging Source NTIS/MT
Control Number 028803440
Origin NTIS
Type CAT