||Initial Submission: Reproduction Study - Cga 18809 Techn. Rat Segment Ii (Test for Teratogenic or Embryotoxic Effects) (Final Report) with Cover Letter Dated 12/11/1991.
||CIBA-GEIGY Corp., Toms River, NJ.; Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Health effects ;
Reproduction/fertility Effects ;
Toxic substances ;
Laboratory animals ;
CAS No 35575-96-3
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Azamethiphos (CAS No. 35575-96-3) was evaluated for developmental toxicity. Twenty-nine, 24, 22, and 24 pregnant Sprague-Dawley rats were treated with 0, 25, 75, and 150 mg/kg/day of the test material, respectively, by oral gavage on days 6-15 of gestation. Feed intake was reduced in the 150 mg/kg/day dose group. Body weight gain was unaffected by treatment. Rates of implantations, embryolethality (resorptions), and average weights of the fetuses were comparable to controls. An increased number of not yet ossified calcanei and phalangeal nuclei of hind-limb was observed at 150 mg/kg/day. These effects were related to the toxic effects on the dams. At 25 and 75 mg/kg/day no treatment- related effects were observed. No teratogenic effects were observed at any treatment level.
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||57Y; 57U; 68G; 99; 44G
||PC A03/MF A03