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RECORD NUMBER: 584 OF 616Main Title | Toxicological Assessment of Hexachloroniphenyl Isomers and 2,3,7,8-Tetrachlorodibenzofuran in Chicks. II. Effects on Drug Metabolism and Porphyrin Accumulation. | |||||||||||
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Author | Goldstein, Joyce A. ; McKinney, James D. ; Lucier, George W. ; Hickman, Patricia ; Bergman., Hinda ; | |||||||||||
CORP Author | National Environmental Research Center, Research Triangle Park, N. C. ;National Inst. of Environmental Health Sciences, Research Triangle Park, N.C. | |||||||||||
Year Published | 1975 | |||||||||||
Stock Number | PB-279 178 | |||||||||||
Additional Subjects | Toxicology ; Pesticides ; Metabolism ; Chlorine organic compounds ; Furans ; Chickens ; Laboratory animals ; Experimental data ; Tables(Data) ; Physiological effects ; Drugs ; Porphyrins ; Liver ; Cytochromes ; Tissues(Biology) ; Enzymes ; Body weight ; Biphenyl/hexachloro ; Reprints ; Furan/dibenzo-tetrachloro ; Polychlorinated biphenyls ; Toxic substances ; Bioaccumulation | |||||||||||
Holdings |
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Collation | 12p | |||||||||||
Abstract | Pure hexachlorobiphenyl (HCB) isomers induce a number of changes in parameters of drug metabolism in the chick including changes in cytochrome P-450, liver weight, and p-nitrophenol glucuronyl transferase, but not in testosterone glucuronyl transferase activity. The most active inducers of drug metabolism were 2,3,4,2',3',4'-HCB and 2,4,6,2',4',6'-HCB, while 2,4,5,2',4',5'-HCB produced intermediate effects and 2,3,6,2'.3',6'-HCB was a poor inducer. All HCBs caused uroporphyrin accumulation and increased delta-aminolevulinic acid (ALA) synthetase activity, but only 3,4,5,3',4',5'-HCB, 2,3,4,2',3',4'-HCB, and 2,4,5,2',4',5'-HCB produced gross accumulation of hepatic porphyrins. Tissue HCB concentrations correlated well with hepatic effecs. 2,3,7,8,-Tetrachlorodibenzofuran (TCDF), a contaminant of commercial polychlorinated biphenyl (PCB) mixtures, had no effects on hepatic ALA synthetase activity, porphyrin accumulation, or glucuronyl transferase. TCDF did produce a slight increase in cytochrome P-450, but the increase was smaller than that produced by HCBs. | |||||||||||
Supplementary Notes | Pub. in Toxicology and Applied Pharmacology 36, p81-92 1976. Prepared in cooperation with National Inst. of Environmental Health Sciences, Research Triangle Park, N.C. | |||||||||||
Availability Notes | Included in the report, Journal Articles on Toxicology. Group 5, PB-279 175. | |||||||||||
Title Annotations | Reprint: Toxicological Assessment of Hexachloroniphenyl Isomers and 2,3,7,8-Tetrachlorodibenzofuran in Chicks. II. Effects on Drug Metabolism and Porphyrin Accumulation, | |||||||||||
PUB Date Free Form | 6 Nov 75 | |||||||||||
Category Codes | 6T; 57Y; 68E; 68G | |||||||||||
NTIS Prices | (Order as PB-279 175, MF A01) | |||||||||||
Primary Description | 500/01 | |||||||||||
Document Type | NT | |||||||||||
Cataloging Source | NTIS/MT | |||||||||||
Control Number | 323737783 | |||||||||||
Origin | NTIS | |||||||||||
Type | CAT |