Main Title |
Biochemical Effects of Repeated Administration of p,p'-DDT on the Squirrel Monkey. |
Author |
Cranmer, M. ;
Peoples, A. ;
Chadwick., R. ;
|
CORP Author |
Environmental Protection Agency, Perrine, Fla. Perrine Primate Lab. |
Year Published |
1970 |
Report Number |
found in PB-280 889 |
Stock Number |
PB-280 895, found in PB-280 889 |
Additional Subjects |
DDT ;
Pesticides ;
Toxicology ;
Insecticides ;
Ingestion(Biology) ;
Biochemistry ;
Monkeys ;
Laboratory animals ;
Experimental data ;
Dosage ;
Concentration(Composition) ;
Lethal dosage ;
Bioassay ;
Liver ;
Hematology ;
Tables(Data) ;
Physiological effects ;
Enzymes ;
Blood plasma ;
Exposure ;
Reprints ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-280 895 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
4p |
Abstract |
p,p'-DDT was administered po in peanut oil to 5 groups of 6 squirrel monkeys at doses of 50, 5, 0.5, 0.05, and 0 mg/kg/day. Blood samples were taken weekly from each animal; several hematologic parameters were determined, and plasma amylase, aldolase, glutamic-pyruvic transaminase, and isocitric dehydrogenase were measured. Two monkeys from each group were killed after 2, 4, and 6 mo and in vitro liver homogenate enzyme activity was measured using p-nitroanisole and ethyl p-nitrophenyl phenylphosphonothioate as substrates. No discernible effects on hematologic values or plasma enzyme levels were observed. The stimulation of the 2 liver homogenate mixed-function oxidases was maximal after 2 mo treatment. There were no significant differences in the levels of homogenate enzyme activity at the 3 sacrifice periods. The monkeys given 50 mg/kg/day all died within 14 wk of starting treatment; deaths did not occur at the other doses. |
Notes |
contained in PB-280 889 titled Journal Articles on Toxicology. Group 14. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 21, p98-101 1972. |
Availability Notes |
Included in the report, Journal Articles on Toxicology, Group 14, PB-280 889. |
Title Annotations |
Reprint: Biochemical Effects of Repeated Administration of p,p'-DDT on the Squirrel Monkey, |
PUB Date Free Form |
5 Oct 70 |
Category Codes |
6T; 6A; 57Y; 57B; 68E |
NTIS Prices |
(Order as PB-280 889, MF A01) |
Primary Description |
500/01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323741180 |
Origin |
NTIS |
Type |
CAT |