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RECORD NUMBER: 40 OF 65

OLS Field Name OLS Field Data
Main Title Micronuclei and Other Nuclear Anomalies in Buccal Smears: A Field Test in Snuff Users.
Author Tolbert, P. E. ; Shy, C. M. ; Allen, J. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;North Carolina Univ. at Chapel Hill. School of Public Health.
Publisher c1992
Year Published 1992
Report Number EPA/600/J-92/445;
Stock Number PB93-141448
Additional Subjects Mouth ; Carcinogenesis ; Tobacco ; Micronucleus tests ; Smokeless tobacco ; Field tests ; Risk factors ; Genetic markers ; Epithelial cells ; Chromosome aberrations ; Public health ; Epidemiologic methods ; Reprints ; Buccal smears ; Snuff
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB93-141448 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/12/1993
Collation 13p
Abstract A revised protocol for the exfoliated cell micronucleus assay was field-tested in a population exposed to a genotoxic agent at levels associated with a significant increase in cancer risk. The standard assay involves microscope examination of epithelial smears to determine the prevalence of micronucleated cells with separate scoring of other nuclear anomalies associated with cytotoxicity and genotoxicity. Prevalence of micronucleated cells was elevated in the snuff users compared to the non-users. The pattern of relative frequencies of several nuclear anomalies provided strong evidence of a cytotoxic effect of snuff.
Supplementary Notes Pub. in American Jnl. of Epidemiology, v134 n8 p840-850, 15 Oct 91. See also PB93-141455. Prepared in cooperation with North Carolina Univ. at Chapel Hill. School of Public Health.
NTIS Title Notes Journal article.
Title Annotations Reprint: Micronuclei and Other Nuclear Anomalies in Buccal Smears: A Field Test in Snuff Users.
Category Codes 57F; 57U
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 307031510
Origin NTIS
Type CAT