Main Title |
Workshop on the Qualitative and Quantitative Comparability of Human and Animal Developmental Neurotoxicity, Work Group 1 Report: Comparability of Measures of Developmental Neurotoxicity in Humans and Laboratory Animals. |
Author |
Stanton, M. E. ;
Spear, L. P. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC.;State Univ. of New York at Binghamton. |
Publisher |
c1990 |
Year Published |
1990 |
Report Number |
EPA/600/J-90/128; |
Stock Number |
PB91-109678 |
Additional Subjects |
Meetings ;
Toxicology ;
Environmental surveys ;
Drugs ;
Laboratory animals ;
Public health ;
Exposure ;
Nervous system disorders ;
Lead(Metal) ;
Mental disorders ;
Comparison ;
Reprints ;
Biological effects ;
Ethyl alcohol ;
Risk assessment ;
Mercury/methyl ;
Polychlorinated biphenyls
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB91-109678 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Assessment measures used in developmental neurotoxicology are reviewed for their comparability in humans and laboratory animals, and their ability to detect comparable adverse effects across species. Compounds used for these comparisons include: abuse substances, anticonvulsant drugs, ethanol, methylmercury, lead, PCBs, and ionizing radiation. At the level of functional category (sensory, motivational, cognitive and motor function, and social behavior), close agreement was found across species for all neurotoxic agents reviewed, particularly at high exposure levels. This was true even though the specific endpoints used to assess these functions often varied substantially across species. In addition, it was found that: (1) the Developmental Neurotoxicology Test Battery presented at the Workshop would have identified the hazard to humans of exposure to the above compounds, although it may have underestimated human risk in some cases; (2) assessment of developmental neurotoxicity should involve evaluation of all categories of function; (3) for most compounds reviewed, the neurotoxic effects of prenatal exposure cannot be attributed to maternal toxicity, and exposure at or just below the threshold for such toxicity is an appropriate upper level for develop-mental neurotoxicity testing; (4) maternal exposure during the postnatal period poses a number of serious methodological problems; and (5) animal studies would better parallel human studies if more emphasis was placed on assessment during development. |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v12 n3 p261-267 Jun 90. Sponsored by State Univ. of New York at Binghamton. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Workshop on the Qualitative and Quantitative Comparability of Human and Animal Developmental Neurotoxicity, Work Group 1 Report: Comparability of Measures of Developmental Neurotoxicity in Humans and Laboratory Animals. |
Category Codes |
57Y; 57U; 57Q; 68 |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
034834671 |
Origin |
NTIS |
Type |
CAT |