Main Title |
On the incorporation of biokinetic and mechanistic data in modeling for risk assessment / |
Author |
Clewell, Harvey J.
|
Publisher |
Utrecht University, |
Year Published |
2007 |
OCLC Number |
823937589 |
ISBN |
9789039344774; 9039344779 |
Subjects |
Hazardous substances--Risk assessment ;
Environmental chemistry ;
Environmental risk assessment
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EKBM |
TD196.C45C64 2007 |
|
Research Triangle Park Library/RTP, NC |
09/08/2014 |
ELBM |
TD196.C45C64 2007 |
|
AWBERC Library/Cincinnati,OH |
01/14/2013 |
|
Collation |
472 p. : ill., charts ; 24 cm. |
Notes |
Includes bibliographical references. |
Contents Notes |
The goal of the studies described in this thesis was to foster the increased use of emerging scientific information and innovative methods in chemical risk assessments, in order to assure the protection of public health while limiting the economic and social consequences of over-regulation. The first part of the thesis presents three studies that were performed to demonstrate approaches for incorporating biokinetic and mechanistic data and mathematical modeling in risk assessment, focusing on mode of action evaluation, physiologically based biokinetic (PBBK) modeling, and benchmark dose-response (BMD) modeling. The second part of the thesis documents three studies that were performed to show the ability of PBBK modeling to describe the interaction between chemical-specific properties, physiology, and age-dependent biochemical processes and the resulting variability in risks across individuals in a population at different ages. The final part of the thesis describes three studies that attempted to make optimal use of available biokinetic and mechanistic data in cancer risk assessments for vinyl chloride, trichloroethylene, and perchloroethylene using the three methodologies discussed in the first section of the thesis. Overall, the research described in this thesis demonstrates that the use of mode-of-action evaluation, PBBK modeling, and quantitative dose-response modeling greatly increases the opportunity for the use of biokinetic and mechanistic data in risk assessment. The resulting risk assessment approaches are more appropriately tailored to the specific chemical and are likely to provide a more accurate assessment of the potential hazards associated with human exposures. The studies in this thesis also demonstrate that the application of PBBK models in risk assessment demands well-formulated statements about the chemical mode of action. It is this requirement for an explicit, mechanistic hypothesis that gives biologically motivated models their power, but at t |
Access Notes |
Also available online. |
PUB Date Free Form |
2007 |
BIB Level |
m |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20140904121549 |
Language |
eng |
Origin |
OCLC |
Type |
CAT |
OCLC Rec Leader |
03413cam 2200337Ka 45020 |