| Main Title |
Effect of Lindane on Intestinal Nitroreductase, Azoreductase, SS-Glucuronidase, Dechlorinase, and Dehydrochlorinase Activity. |
| Author |
Chadwick, R. W. ;
Chang, J. ;
Forehand, L. R. ;
Long, J. E. ;
Duffy, M. C. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;North Carolina Univ. at Chapel Hill. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| Publisher |
c1990 |
| Year Published |
1990 |
| Report Number |
EPA/600/J-90/346; |
| Stock Number |
PB91-163600 |
| Additional Subjects |
Lindane ;
Small intestine ;
Enzymology ;
Glucuronidase ;
Rats ;
Intestinal mucosa ;
Gas chromatography ;
Enterobacteriaceae ;
Reprints ;
Nitroreductase ;
Azoreductase ;
Dechlorinase ;
Dehydrochlorinase
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB91-163600 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
11p |
| Abstract |
The effect of daily p.o. injections of 20 mg/kg lindane on nitroreductase, azoreductase, B-glucuronidase, dechlorinase and dehydrochlorinase enzyme activity in the rat intestinal tract was investigated after 2 weeks and 5 weeks of treatment. Antibiotics were administered to half of the treated rats after 4 weeks of treatment. Results of the study indicated that lindane significantly increased nitro reductase and azoreductase activity in the small intestine, that there were regional differences in the effect of lindane as well as differences dependent on the exposure duration. The results also suggest the presence of substantial levels of mucosal enzyme in the small intestine. |
| Supplementary Notes |
Pub. in Pesticide Biochemistry and Physiology, v38 p48-56 Sep 90. Prepared in cooperation with North Carolina Univ. at Chapel Hill, and Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Effect of Lindane on Intestinal Nitroreductase, Azoreductase, SS-Glucuronidase, Dechlorinase, and Dehydrochlorinase Activity. |
| Category Codes |
68E; 57Y; 57F |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
113027420 |
| Origin |
NTIS |
| Type |
CAT |
