Main Title |
In vitro microbiological mutagenecity and unscheduled DNA synthesis studies of eighteen pesticides / |
Author |
Simmon, Vincent F.
|
CORP Author |
SRI International, Menlo Park, CA.;Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
U.S. Environmental Protection Agency, Health Effects Research Laboratory, |
Year Published |
1979 |
Report Number |
EPA 600/1-79/041; EPA-68-01-2458 |
Stock Number |
PB80-133226 |
OCLC Number |
37391220 |
Subjects |
Mutagenesis ;
Pesticides--Toxicology
|
Additional Subjects |
Deoxyribonucleic acids ;
Pesticides ;
Mutagens ;
Bacteria ;
In vitro analysis ;
Escherichia coli ;
Microbiology ;
Synthesis ;
Risk ;
Salmonella typhimurium ;
Enterobacteriaceae ;
Bioassay ;
Mutagenesis ;
Saccharomyces cerevisiae
|
Internet Access |
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
EJBD |
EPA 600-1-79-041 |
|
Headquarters Library/Washington,DC |
04/23/2014 |
EKBD |
EPA-600/1-79-041 |
|
Research Triangle Park Library/RTP, NC |
06/30/2000 |
EKCD |
EPA-600/1-79-041 |
|
CEMM/GEMMD Library/Gulf Breeze,FL |
05/29/2018 |
ELBD ARCHIVE |
EPA 600-1-79-041 |
Received from HQ |
AWBERC Library/Cincinnati,OH |
10/04/2023 |
NTIS |
PB80-133226 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
x, 165 pages : tables ; 28 cm. |
Abstract |
Eighteen pesticides being reviewed as a part of the EPA Substitute Chemical Program were tested for mutagenic activity by the following in vitro procedures: (1) Reverse mutation in Salmonella typhimurium strains TA1535, TA1537, TA1538, TA98, and TA100 and in Escherichia coli WP2 uvrA. (2) Induction of mitotic recombination in the yeast Saccharomyces cerevisiae D3. (3) Relative toxicity assays in DNA repair-proficient and -deficient strains of E. coli (strains W3110 and p3478, respectively) and of Bacillus subtilis (strains H17 and M45 respectively). (4) Unscheduled DNA synthesis (UDS) in human fibroblasts (WI-38 cells). Nine of the 18 pesticides were mutagenic in one or more of the assays. One compound, demeton, was mutagenic in all of them. Trichlorofon was mutagenic in all the assays except those for relative toxicity. Acephat was mutagenic in the Salmonella typhimurium in TA100, Saccharomyces cerevisiae D3, and UDS assays. Dicamba, 2,4-D acid, 2,4-DB acid, and propanil were positive only in the assay for relative toxicity. Disulfoton was positive only in the UDS assay, and then only in the absence of the metabolic activation system. Crotoxyphos was positive only in the S. cerevisiae D3 assay. |
Notes |
"EPA-600/1-79-041." "Contract No. 68-01-2458." Includes bibliographical references (pages 163-164). |
Place Published |
Research Triangle Park, NC |
Corporate Au Added Ent |
Health Effects Research Laboratory (Research Triangle Park, N.C.); SRI International. |
Title Ser Add Ent |
Research reporting series. Environmental health effects research ; EPA-600/1-79-041. |
PUB Date Free Form |
October 1979 |
Series Title Untraced |
Environmental health effects research series ; EPA-600/1-79-041 |
NTIS Prices |
PC A09/MF A01 |
BIB Level |
m |
Medium |
unmediated |
Content |
text |
Carrier |
volume |
Cataloging Source |
OCLC/T |
OCLC Time Stamp |
20180523082227 |
Language |
eng |
Origin |
OCLC |
Type |
MERGE |
OCLC Rec Leader |
01838cam 2200457Ka 45010 |