||Effects of p-Xylene Inhalation on Axonal Transport in the Rat Retinal Ganglion Cells.
Padilla, S. S. ;
Lyerly, D. P. ;
||Health Effects Research Lab., Research Triangle Park, NC.;Northrop Services, Inc., Research Triangle Park, NC.
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The intent of the study was to determine the effect of intermittent, acute, and subchronic p(bar)-xylene exposure on the axonal transport of proteins and glycoproteins within the rat retinofugal tract. A number of different exposure regimens were tested ranging from 50 ppm for a single 6-hr exposure to 1600 ppm 6 hr/day, 5 days/week, for a total of 8 exposure days. Immediately following removal from the inhalation chambers rats were injected intraocularly with (35S)methionine and (3H)fucose (to label retinal proteins and glycoproteins, respectively) and the axonal transport of labeled macromolecules to axons (optic nerve and optic tract) and nerve endings (lateral geniculate body and superior colliculus) was examined 20 hr after precursor injection. Only relatively severe exposure regimens (i.e., 800 or 1600 ppm 6 hr/day, 5 days/week, for 1.5 weeks) produced significant reductions in axonal transport; there was a moderate reduction in the axonal transport of 35S-labeled proteins in the 800-ppm-treated group which was more widespread in the 1600 ppm-treated group. Transport of 3H-labeled glycoproteins was less affected. (Copyright (c) 1989 by Academic Press, Inc.)
||Pub. in Toxicology and Applied Pharmacology, v101 p390-398 Dec 89. Sponsored by Northrop Services, Inc., Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Effects of p-Xylene Inhalation on Axonal Transport in the Rat Retinal Ganglion Cells.
||PC A03/MF A01