Main Title |
Hexachlorophene Effects on the Rat Brain, Study of High Doses by Light and Electron Microscopy. |
Author |
Kimbrough, Renate D. ;
Gaines., Thomas B. ;
|
CORP Author |
Food and Drug Administration, Chamblee, Ga. |
Year Published |
1970 |
Stock Number |
PB-280 831 |
Additional Subjects |
Toxicology ;
Bactericides ;
Pesticides ;
Fungicides ;
Bioassay ;
Rats ;
Brain ;
Physiological effects ;
Dosage ;
Electron microscopy ;
Laboratory animals ;
Concentration(Composition) ;
Dosage ;
Ingestion(Biology) ;
Diets ;
Weight(Mass) ;
Experimental data ;
Pathology ;
Central nervous system ;
Toxicity ;
Reprints ;
Hexachlorophene ;
Brain edema ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-280 831 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
Hexachlorophene was fed to female adult Sherman strain rats at 500 ppm (25 mg/kg/day) for 14 and 10 weeks in two consecutive studies. After two weeks on the diet containing hexachlorohene, the rats developed leg weakness which progressed to paralysis in three to five weeks. After ten weeks on these diets in the second study, hexachlorophene was discontinued; the rats regained almost complete recovery of leg function within six weeks. The brains of the rats that had ingested hexachlorophene weighed significantly more than those of controls and returned to normal in six weeks. The lesions produced by hexachlorophene in the rat brains represented cerebral edema limited to the white matter, which resembles diffuse spongy deggeneration of the white matter of the brain described in infants. |
Supplementary Notes |
Pub. in Archives of Environmental Health, v23 p114-118, Aug 71. |
Availability Notes |
Included in the report, Journal Articles on Toxicology. Group 16, PB-280 830. |
Title Annotations |
Reprint: Hexachlorophene Effects on the Rat Brain, Study of High Doses by Light and Electron Microscopy, |
PUB Date Free Form |
13 Aug 70 |
Category Codes |
6T; 57Y; 68G; 68E |
NTIS Prices |
(Order as PB-280 830, MF A01) |
Primary Description |
500/01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323740886 |
Origin |
NTIS |
Type |
CAT |