||Personal, Indoor and Outdoor Particulate Air Pollution and Heart Rate Variability in Elderly Subjects with Coronary Artery Disease.
R. J. Delfino ;
||California Univ., Irvine. Coll. of Medicine.; California State Air Resources Board, Sacramento.; California Environmental Protection Agency, Sacramento.
Air pollution effects ;
Cardiovasuclar diseases ;
Elderly persons ;
Environmental exposure ;
Health effects ;
Heart rate ;
Risk factors ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Decreased heart rate variability (HRV) is a marker of autonomic dysfunction and has been associated with future cardiac morbidity and mortality. HRV has been inconsistently associated with exposure to particulate matter (PM) air pollution. Fewer studies have examined whether air pollution exposure is a risk factor for cardiac arrhythmias. We aimed in this study to evaluate the relationships of heart rate variability and cardiac arrhythmias to PM exposures. Heart rate variability and arrhythmias were measured with ambulatory electrocardiographs using available raw data collected in a cohort panel study the National Institutes of Health, National Institute of Environmental Health Sciences (funded by NIH NIEHS R01 ES-012243). Electrocardiograph data (8,952 person-hours) were collected in 50 nonsmokers with coronary artery disease age 71 years and older living in four retirement communities in the Los Angeles air basin. Exposures included hourly markers of traffic-related PM and secondary organic aerosols, daily size-fractionated particle mass, and hourly outdoor criteria gases. Subjects were genotyped for the glutathione S-transferase M1 and T1 null (risk) alleles. Repeated measures regression analyses were adjusted for actigraph-derived physical activity and heart rate, temperature, day of week, season, and community location.
||Sponsored by California State Air Resources Board, Sacramento. and California Environmental Protection Agency, Sacramento.
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|PUB Date Free Form
||17 May 2013
||68A; 68G; 57E; 57U; 92C