| Main Title |
Mutagenic Screening of Three Dyes for Marker Grenades in the Salmonella Reversion Assay and the L5178Y/TK+/-Mouse Lymphoma Assay. |
| Author |
Moore, M. M. ;
Claxton, L. ;
Houk, V. ;
Nelson, G. M. ;
Brock, K. ;
|
| CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Genetic Toxicology Div. ;Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| Publisher |
Dec 88 |
| Year Published |
1988 |
| Report Number |
EPA/600/1-88/007; |
| Stock Number |
PB89-131346 |
| Additional Subjects |
Mutagenicity tests ;
Dyes ;
Grenades ;
Toxicity ;
Salmonella typhimurium ;
Lymphoma ;
Cells(Biology) ;
Solvent Red 1 ;
Disperse Blue 3 ;
Disperse Red 11 ;
Occupational safety and health ;
Ethene/bromo
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB89-131346 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
144p |
| Abstract |
Dyes are used by the military in M18 marker signaling grenades. The U.S. Army is concerned with evaluating any potential health hazards that might result from personal contact with the dyes in the industrial setting. Three dyes (Solvent Red 1, Disperse Blue 3, and Disperse Red 11) were tested for mutagenicity in the Salmonella reversion assay and the L5178Y/TK(sup +/-) mouse lymphoma assay. The in vitro assays were performed both with and without exogenous activation provided by Aroclor induced rat liver S-9. In the Salmonella assay, Solvent Red 1 was positive with S-9 activation in strain TA100 and negative to questionably positive in the other strains and activation conditions. Disperse Blue 3 was positive with S-9 activation in strain TA1537 and negative to questionably positive under the other test conditions. Disperse Red 11 was positive with S-9 activation in strain TA102, but negative to weakly positive with the other strains and activation conditions. Both Disperse Blue 3 and Disperse Red 11 were positive both with and without S-9 activation in the mouse lymphoma assay. Solvent Red 1 could not be tested without activation. With S-9 activation, it was weakly positive. |
| Supplementary Notes |
See also AD-A152 110. Portions of this document are not fully legible. Prepared in cooperation with Environmental Health Research and Testing, Inc., Research Triangle Park, NC. |
| NTIS Title Notes |
Technical rept.. |
| Category Codes |
57Y; 57U; 41I; 79A; 94D |
| NTIS Prices |
PC A07/MF A01 |
| Primary Description |
600/11 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
902622121 |
| Origin |
NTIS |
| Type |
CAT |
