Main Title |
Chronic Toxicity Studies on 1,3,5-Trinitrobenzene in Fischer 344 Rats. |
Author |
Reddy, T. V. ;
Daniel, F. B. ;
Olson, G. R. ;
Wiechman, B. ;
Torsella, J. ;
|
CORP Author |
Environmental Protection Agency, Cincinnati, OH. Risk Reduction Engineering Lab. |
Publisher |
Feb 96 |
Year Published |
1996 |
Report Number |
MIPR-93MM3558; |
Stock Number |
AD-A315 216/2 |
Additional Subjects |
Benzene ;
Toxicity ;
Methemoglobin ;
Brain ;
Rats ;
Powders ;
Abstracts ;
Chemistry ;
Deposition ;
Drops ;
Weight ;
Adverse conditions ;
Laboratories ;
Males ;
Immunology ;
Pigments ;
Diet ;
Body weight ;
Females ;
Sex ;
Spleen ;
Histology ;
Kidneys ;
Hematology ;
Trinitrobenzene ;
Chronic oral toxicity ;
Alpha 2u globulin ;
Hyaline droplets ;
Tnb(Trinitrobenzene)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
AD-A315 216/2 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
806p |
Abstract |
Chronic toxic effects of I ,3,5-tnnitriotrobenzene (TNB) in male and female Fischer rats were evaluated by feeding certified powdered laboratory chow diet supplemented with varied concentrations of TNB (0, 5, 60 and 300 mg/kg diet). The study was designed to accommodate three interim sacrifices (10 rats/group/sex) at 90, 180 and 365 days. The final sacrifice was performed after two years. All data related to these interim sacrifices are presented independently in appendices J to L. The calculated average TNB consumption for females was 0.23, 2.68 and 13.31 mg/kg/day and was 0.22, 2.64 and 13.44 mg/kg/day for males. Terminal body weights were significantly decreased in both sexes in the 300 mg/kg group. Relative spleen weights were decreased in both sexes in the 300 mg/kg group while brain weights were increased in females in this same group. Methemoglobin was increased in both sexes in the 300 mg/kg group while other hematological effects noted at the interim sacrifice times were not evident at two years. Histopathological examinations suggested treatment related changes in both sexes involving the kidneys (cytoplasmic/hyaline droplets) in the 60 and 300 mg/kg groups and the spleen (erythroid cell hyperplasia and pigment deposition) in the 300 mg/kg group. The cytoplasmic/hyaline droplets were characterized by immunohistochemistry as alpha-2u-globulin. These renal droplets were also noted at the interim sacrifice times. A no observed adverse effect level (NOAEL) was established in this study at 2.68 mg/kg b.w./day for F-344 rats administered TNB for two years. |
Availability Notes |
Availability: Document partially illegible. |
NTIS Title Notes |
Final rept. 1 May 93-30 Apr 95. |
Category Codes |
57Y; 99D |
NTIS Prices |
PC A99/MF E08 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
703401110 |
Origin |
NTIS |
Type |
CAT |