| Main Title |
Neurotoxicity of Acrylamide and 2,5-Hexanedione in Rats Evaluated Using a Functional Observational Battery and Pathological Examination. |
| Author |
Shell, L. ;
Rozum, M. ;
Jortner, B. S. ;
Ehrich, M. ;
|
| CORP Author |
Virginia-Maryland Regional Coll. of Veterinary Medicine, Blacksburg, VA. ;Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Statistics.;Health Effects Research Lab., Research Triangle Park, NC. |
| Publisher |
c1992 |
| Year Published |
1992 |
| Report Number |
EPA-68D80098; EPA/600/J-94/396; |
| Stock Number |
PB95-126488 |
| Additional Subjects |
Acrylamides ;
Nervous system ;
Pathology ;
Toxicity ;
Esterases ;
Dose-response relationships ;
Reprints ;
Functional observational battery ;
Hexanediones
|
| Holdings |
| Library |
Call Number |
Additional Info |
Location |
Last
Modified |
Checkout
Status |
| NTIS |
PB95-126488 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
| Collation |
14p |
| Abstract |
The clinical effects of two neurotoxicants, acrylamide and 2,5-hexanedione, were compared in rats using a functional observational battery (FOB), which includes a series of home cage and open-field observations, sensorimotor measurements, and physiological parameters. Neurotoxicity was assessed weekly in adult male Long-Evans rats after initiation of IP administration of 9 doses of acrylamide (12, 15, or 50 mg/kg given 3 times a week) and 28 doses of 2,5-hexanedione (150, 225, and 350 mg/kg given daily). Using the FOB, it was possible to detect differences in neurotoxic effects of these two chemicals. Acrylamide significanly affected home cage posture, foot splay and time on the rotarod, whereas 2,5-hexanedione altered hindlimb grip strength and the approach response. Both compounds caused changes in ability to walk, right, and maintain agility on a rotarod within 21 days from initiation of toxicant administration. In addition, both compounds caused dose-dependent rats and at 28 days in rats treated with 2,5-hexanedione. Administration of acrylamide also decreased activities of neural esterase. The study indicated that the FOB could be used to detect evidence of neurotoxicity in rats treated with acrylamide and 2,5-hexanedione, with alterations evident even before pathological changes were induced by 2,5-hexanedione. (Copyright (c) 1992 Pergamon Press Ltd.) |
| Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v14 n4 p273-283 1992. See also PB92-113323. Prepared in cooperation with Virginia Polytechnic Inst. and State Univ., Blacksburg. Dept. of Statistics. Sponsored by Health Effects Research Lab., Research Triangle Park, NC. |
| NTIS Title Notes |
Journal article. |
| Title Annotations |
Reprint: Neurotoxicity of Acrylamide and 2,5-Hexanedione in Rats Evaluated Using a Functional Observational Battery and Pathological Examination. |
| Category Codes |
57Y; 57S; 57O |
| NTIS Prices |
PC A03/MF A01 |
| Primary Description |
600/10 |
| Document Type |
NT |
| Cataloging Source |
NTIS/MT |
| Control Number |
433519187 |
| Origin |
NTIS |
| Type |
CAT |
