Main Title |
Maturational Changes in Dermal Absorption of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Fischer 344 Rats. |
Author |
Anderson, Y. B. ;
Jackson, J. A. ;
Birnbaum, L. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. ;ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
Publisher |
c1993 |
Year Published |
1993 |
Report Number |
EPA/600/J-93/331; |
Stock Number |
PB93-229490 |
Additional Subjects |
Skin absorption ;
Toxicity ;
Tetrachlorodibenzodioxin ;
Rats ;
Tissue distribution ;
Feces ;
Body composition ;
Dose-response relationships ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB93-229490 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
9p |
Abstract |
Maturational changes in potential for systemic exposure to TCDD following dermal application of a low dose (200 pmol) of this chemical were examined in male Fischer 344 rats. Absorption, tissue distribution, and elimination of TCDD, measured as TCDD-derived radioactivity, were examined 72 hr after dermal application of 200 pmol ((3)H)TCDD (111 pmol/sq cm applied over 1.8 sq cm) to the interscapular region of 3-, 5-, 8-, 10-, and 36-week-old rats. Dermal absorption was greatest in 3-week-old rats, decreasing to approximately 80 pmol (approximately 40%) in 5-, 8-, and 10-week-old rats and to 45 pmol (approximately 22%) in 36-week-old rats. In each age group, 70 to 80% of the radioactivity remaining at the application site 72 hr after dosing could be removed with acetone swabs. Major tissue depots of radioactivity were liver and fat; skin and muscle were minor depots. Adipose tissue content (Y) increased linearly with body weight. (X),Y = 0.03X + 2.1 (R squared = 0.95). Results indicate that TCDD is absorbed to a greater degree through skin of very young animals and that a significant decrease in potential for systemic exposure may occur during maturation and again during aging. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology, v119 n2 p214-220 Apr 93. Presented at the Annual Society of Toxicology Meeting, Miami Beach, FL., February 12-16, 1990. Prepared in cooperation with ManTech Environmental Technology, Inc., Research Triangle Park, NC. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Maturational Changes in Dermal Absorption of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) in Fischer 344 Rats. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
328023491 |
Origin |
NTIS |
Type |
CAT |