Main Title |
Effect of Perinatal Monosodium Glutamate Administration on Visual Evoked Potentials of Juvenile and Adult Rats. |
Author |
Rigdon, G. C. ;
Boyes, W. K. ;
Dyer, R. S. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. |
Publisher |
c1989 |
Year Published |
1989 |
Report Number |
EPA/600/J-89/229; |
Stock Number |
PB90-146010 |
Additional Subjects |
Toxicity ;
Damage ;
Rats ;
Exposure ;
Flash lamps ;
Optic nerve ;
Dosimetry ;
Retina ;
Graphs(Charts) ;
Aging(Biology) ;
Reprints ;
Sodium glutamate ;
Visual evoked potentials ;
Dose-response relationships ;
Maternal-fetal exchange
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB90-146010 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
Administration of high doses of monosodium glutamate (MSG) to rats during the first postnatal week results in severe losses of retinal ganglion cells and interneurons in the retina. The study was conducted to determine what effect this severe retinal damage would have upon the ontogeny of rat flash evoked potentials (FEPs) and the adult pattern reversal evoked potentials(PREP). MSG (4 mg/g) or isotonic saline was administered to rat pups daily from postnatal day (PND) 2 until PND 9. FEPs were recorded following 2 stimulation frequencies from unanesthetized, unrestrained MSG treated and control rats on PND 15, PND 22, and PND 60 or older. PREPs were recorded from unanesthetized, restrained rats older than PND 60 from each treatment group. On PND 15, 9 of 12 control animals exhibited responses to light flashes, while only 4 of 12 MSG treated animals did so. All animals from both treatment groups exhibited FEPs on PND 22. All FEP peak latencies were significantly increased in MSG treated animals with the magnitude of the effect being greater during development. Perinatal MSG treatment results in profound alterations in FEP ontogeny and the generation of PREPs. |
Supplementary Notes |
Pub. in Neurotoxicology and Teratology, v11 p121-128 1989. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Effect of Perinatal Monosodium Glutamate Administration on Visual Evoked Potentials of Juvenile and Adult Rats. |
Category Codes |
57Y; 57S |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/10 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
007530371 |
Origin |
NTIS |
Type |
CAT |