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RECORD NUMBER: 9 OF 929

OLS Field Name OLS Field Data
Main Title Acute Effects of Amitraz on the Acoustic Startle Response and Motor Activity.
Author Crofton, K. M. ; Boncek, V. M. ; Reiter., L. W. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Northrop Services, Inc., Research Triangle Park, NC.
Publisher c1989
Year Published 1989
Report Number EPA/600/J-89/468;
Stock Number PB91-115998
Additional Subjects Pesticides ; Animal behavior ; Acoustics ; Body temperature ; Body weight ; Rats ; Mortality ; Reprints ; Amitraz ; Motor activity ; Startle reaction ; Dose-response relationships
Holdings
Library Call Number Additional Info Location Last
Modified
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Status
NTIS  PB91-115998 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 03/04/1991
Collation 13p
Abstract To characterize further the behavioral toxicity of amitraz, comparisons were made between the effects of amitraz on motor activity, the acoustic startle response, body temperature, and body weight in male Long-Evans rats. Acute dosage-effect and time-course determinations of motor activity were made using figure-eight mazes. Dosage-effect and time-course determinations for the acoustic startle response were measured using a 13 KHZ, 120 dB(A), 40 ms tone as the eliciting stimulus, at each of three background white-noise levels. Amitraz was administered orally in the vehicle ('Emulphor'+ethanol+saline,d a dosage- and time-dependent decrease in motor activity which lasted from 4 to 96 h post-administration. The effects of amitraz on the acoustic startle response consisted of an increased latency and a decreased amplitude and sensitization. The time-course of effects on the acoustic startle response were more transient (4-24 h) than the effects on motor activity. Amitraz-exposed animals had decreased body weight that did not return to control levels until 120 h (five days) post-administration. (Copyright (c) 1989 Society of Chemical Industry.)
Supplementary Notes Pub. in Pesticide Science, v27 n1 p1-11 Aug 89. Prepared in cooperation with Northrop Services, Inc., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Acute Effects of Amitraz on the Acoustic Startle Response and Motor Activity.
Category Codes 57Y; 57S; 68E
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 101123348
Origin NTIS
Type CAT