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RECORD NUMBER: 11 OF 929

OLS Field Name OLS Field Data
Main Title Acute Effects of Ethanol on Pattern Reversal and Flash-Evoked Potentials in Rats and the Relationship to Body Temperature.
Author Boyes, W. K. ; Hetzler, B. E. ; Dyer, R. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. Neurotoxicology Div. ;Lawrence Univ., Appleton, WI. Dept. of Psychology.
Publisher c1993
Year Published 1993
Report Number EPA/600/J-93/101;
Stock Number PB93-175701
Additional Subjects Ethanols ; Body temperature ; Visual evoked potentials ; Patterns ; Toxicology ; Rats ; Graphs(Charts) ; Reaction time ; Dose-response relationships ; Reprints ;
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NTIS  PB93-175701 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 08/23/1993
Collation 14p
Abstract The effects of acute ethanol treatment on flash and pattern reversal visual evoked potentials (FEPs and PREPs, respectively) were examined in three experiments using Long-Evans rats. The relationships of evoked potential parameters with blood ethanol concentration and body temperature were examined. In Experiment 1, rats were treated i.p. with vehicle or 0.5, 1.0 or 2.0 g ethanol/kg body weight, and tested 30 min later. The 2.0 g/kg group had prolonged latencies of PREP peaks, no changes in PREP peak-to-peak amplitudes, and lower body temperatures than saline-treated controls. The peak latency shifts were significantly correlated with both blood ethanol concentration and body temperature, and were of a magnitude to be expected from similar changes in body temperature alone. Experiment 2 measured both PREPs and paired-flash FEPs in rats 30 min after injection of either 0, 0.5 or 2.0 g/kg ethanol. PREP changes were found following treatment with the high dose which were similar to those of Experiment 1. Some FEP peak latencies were prolonged and peak-to-peak amplitudes were reduced by both doses of ethanol, despite the fact that body temperatures were reduced at only the high dose. At 2.0 g/kg ethanol, the FEP changes in latency, but not amplitude, were in accordance with what would be expected from body temperature changes alone. The third study attempted to investigate the role of reduced body temperature in producing the visual evoked potential changes by testing at room temperatures of 22 or 30 C. Contrary to expectations, the rats receiving 2 g/kg ethanol were approx. 1 C cooler than controls at both room temperatures. (Copyright (c) 1993 Elsevier Science Publishers B.V.)
Supplementary Notes Pub. in International Jnl. of Psychophysiology, v14 p27-39 1993. Prepared in cooperation with Lawrence Univ., Appleton, WI. Dept. of Psychology.
NTIS Title Notes Journal article.
Title Annotations Reprint: Acute Effects of Ethanol on Pattern Reversal and Flash-Evoked Potentials in Rats and the Relationship to Body Temperature.
Category Codes 57Y; 57I; 57S
NTIS Prices PC A03/MF A01
Primary Description 600/10
Document Type NT
Cataloging Source NTIS/MT
Control Number 316130735
Origin NTIS
Type CAT