Full Record Display for the EPA National Library Catalog


OLS Field Name OLS Field Data
Main Title Acute Oral Toxicity Study of n,n,n,n-Tetramethyl-1, 6-hex Anediamine and Guinea Pig Maximization of n,n-Dimethyl-1,3-Propanediamine with Attachement and Cover Letter dated 04/30/1987.
CORP Author Allied-Signal, Inc., Morristown, NJ.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 5 May 1987
Year Published 1987
Report Number FYI-OTS-0587-0545;
Stock Number OTS-0000545-0
Additional Subjects Toxicity ; Ingestion ; Guinea pigs ; Laboratory animals ; Body weight ; Dose rates ; Gavage ; N,N-Dimethyl-1,3-Propanediamine ; N,N,N',N'-Tetramethyl- 1,6-Hexanediamine (TMHD) ; TMHD ; Acute oral toxicity
Library Call Number Additional Info Location Last
NTIS  OTS-0000545-0 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 10/08/2007
Collation 286p
Abstract N,N,N',N'-Tetramethyl- 1,6-Hexanediamine (TMHD), Sample No. 8361-12, was evaluated in male and female Fischer 344 rats for acute oral toxicity. The test material was administered by gavage at dose levels ranging from0.1 to 1.0 mL/kg. One group of animals from each sex was dosed with distilled water and served as controls. TMHD caused 100% lethality in both sexes at dose levels of 0.5 and 1.0 mL/kg. No females died at a dose of 0.1 at/kg while 2 of 5 males (40%) died at this dose level. The oral LOSO for this material in the rat should be considered to be between 0.25 and 0.5 mL/kg for females and 0.1 and 0.5 mL/kg for males. TMHD caused significant depressions in absolute body weight and body weight gains in both sexes. A generalized depression in neuromuscular function occurred following exposure with peripheral, central and autonomic functions being affected. A number of clinical observations and necropsy findings suggested that TMHD was markedly damaging to the gastrointestinal system, particularly the stomach and surrounding organs. Microscopic examination revealed necrosis of the gastrointestinal tract, localized peritonitis and necrosis of the liver and pancreas. Additional lesions were identified in the lung, liver, kidneys, thymus, lymph nodes and spleen which were directly or indirectly related to exposure to TMHD. A no-effect level was not established in this study.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Category Codes 57Y
NTIS Prices PC A14/MF$25.00
Document Type NT
Cataloging Source NTIS/MT
Control Number 019101000
Origin NTIS
Type CAT