Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 20 OF 1173

OLS Field Name OLS Field Data
Main Title Absorption, Distribution, Excretion, and Metabolism of a Single Oral Dose of o-Ethyl o-4-Nitrophenyl Phenylphosphonothioate in Hens.
Author Abou-Donia, M. B. ; Reichert, B. L. ; Ashry, M. A. ;
CORP Author Duke Univ. Medical Center, Durham, NC.;Health Effects Research Lab., Research Triangle Park, NC.
Year Published 1983
Report Number EPA-R-806400; EPA/600/J-83/345;
Stock Number PB86-210630
Additional Subjects Toxicology ; Chickens ; Dosage ; Absorption ; Distribution ; Excretion ; Metabolism ; Reprints ; Phenylphosphonothioate
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  PB86-210630 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 06/21/1988
Collation 13p
Abstract The disposition and metabolism of a single oral 10 mg/kg (LD50) of uniformly phenyl-labeled (14C)EPN (O-ethyl O-4 nitrophenyl (14C) phenylphosphonothioate) were studied in adult hens. The birds were protected from acute toxicity with atropine sulfate. Three treated hens were killed at each time interval (days): 0.5, 2, 4, 8, 12. Radioactivity was adsorbed from the gastrointestinal tract and distributed in all tissues. Most of the dose was excreted in the combined urinary-fecal excreta (74%). Only traces of the radioactivity (0.2%) were detected in expired CO2. Most of the excreted radioactive materials were identified as phenylphosphonic acid (PPA), O-ethyl phenylphosphonic acid (EPPA), and O-ethyl phenylphosphonothioc acid (EPPTA). Radioactivity in tissues reached a peak of 11.8% in 12 days. The highest concentration of radioactivity was present in the liver followed by bile, kidney, adipose tissue, and muscle. EPN was the major compound identified in brain, spinal cord, sciatic nerve, kidney, and plasma.
Supplementary Notes Pub. in Toxicology and Applied Pharmacology 70, p18-28 Mar 83. Sponsored by Health Effects Research Lab., Research Triangle Park, NC.
NTIS Title Notes Journal article.
Title Annotations Reprint: Absorption, Distribution, Excretion, and Metabolism of a Single Oral Dose of o-Ethyl o-4-Nitrophenyl Phenylphosphonothioate in Hens.
PUB Date Free Form c1983
Category Codes 6T; 6O; 57Y; 57Q
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 622719307
Origin NTIS
Type CAT