Full Record Display for the EPA National Library Catalog

RECORD NUMBER: 199 OF 1173

OLS Field Name OLS Field Data
Main Title Comparative Toxicity to Rats of Methoxyacetone and Five Other Aliphatic Ketones in their Drinking Water with Cover Letter.
CORP Author Union Carbide Corp., Danbury, CT.;Environmental Protection Agency, Washington, DC. Office of Toxic Substances.
Publisher 23 Mar 1977
Year Published 1977
Report Number 878212140;
Stock Number OTS-0206068
Additional Subjects Toxicity ; Neurotoxicity ; Ketones ; Alaphatic ketones ; Drinking water ; Laboratory animals ; Rats ; Dosage ; Concentrations ; Comparisons ; Methoxyacetone ; Methyl isobutyl ketone ; CAS No. 108-10-1
Holdings
Library Call Number Additional Info Location Last
Modified
Checkout
Status
NTIS  OTS-0206068 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. NTIS 09/29/2008
Collation 58p
Abstract The toxicity of methoxyacetone was compared to that of methyl n-butyl ketone and a series of four other aliphatic ketones (diethyl ketone, ethyl n- buty1 ketone, methyl isobutyl ketone-, methyl tert-butyl ketone) with particular reference to neurotoxicity. Preliminary studies were performed to establish toxic dosage levels of the ketones, which were administered in drinking water for seven days at concentrations of 0.5% and 1% (estimated to be equivalent to approx. 0.3 to 0.9 gm/kg/day). Reduced food and water intake and low body weight gains probably reflected rejection of the water because of taste. The concentrations used were at or near maximum water solubility of most of the ketones, methoxyacetone being the most notable exception. Methoxyacetone produced no toxic effects at these concentrations or at 2%, but 6% and 20% solutions of this material for 7 days produced dosage-related effects similar to those of the other ketones.
Supplementary Notes The quality of the documents listed in the Office of Toxic Substances database may not meet usual NTIS standards but are included to further the opportunity for the scientific and technical community to locate materials which may not be available elsewhere. The content is the responsibility of OTS. Prepared in cooperation with American Petroleum Inst., Washington, DC.
Availability Notes Product reproduced from digital image. Order this product from NTIS by: phone at 1-800-553-NTIS (U.S. customers); (703)605-6000 (other countries); fax at (703)605-6900; and email at orders@ntis.gov. NTIS is located at 5285 Port Royal Road, Springfield, VA, 22161, USA.
Category Codes 57Y
NTIS Prices PC A05/MF A01
Document Type NT
Cataloging Source NTIS/MT
Control Number 009400310
Origin NTIS
Type CAT