||Comparative Renal and Hepatotoxicity of Halomethanes: Bromodichloromethane. Bromoform, Chloroform, Dibromochloromethane and Methylene Chloride.
Condie, L. W. ;
Smallwood, C. L. ;
Laurie, R. D. ;
||Health Effects Research Lab., Research Triangle Park, NC.
Potable water ;
Water pollution ;
Halogen organic compounds ;
Laboratory animals ;
Hippuric acid/amino ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The subchronic renal and hepatotoxicities of five selected halomethanes, which are drinking water contaminants, were evaluated following a 14-day exposure period. Bromodichloromethane, bromoform, chloroform, dibromochloromethane and methylene chloride were administered at three dose levels. Toxicity was evaluated by measuring increases in total body weight, active uptake of p-aminohippuric acid into renal cortical slices, blood urea nitrogen, serum creatinine and serum glutamate--pyruvate transaminase levels and by performing a histopathologic examination of liver and kidney tissues. At the dose level employed in these experiments, dose-related effects on the liver and kidney were seen with the uptake of p-aminohippuric acid into kidney slices and with the histopathologic evaluation of tissues. The other parameters revealed adverse renal and hepatic effects in only the high dose groups. Treatment-related effects seen in the methylene chloride exposed mice were less pronounced than in the other halomethane treatment groups. In general, histopathological changes were the most sensitive indicators of both liver and kidney damage.
||Pub. in Jnl. of Drug and Chemical Toxicology, 6 n6 p563-578, 1983.
|NTIS Title Notes
||Reprint: Comparative Renal and Hepatotoxicity of Halomethanes: Bromodichloromethane. Bromoform, Chloroform, Dibromochloromethane and Methylene Chloride.
|PUB Date Free Form
||6T; 57Y; 68D
||PC A02/MF A01