Main Title |
Subchronic Toxicology of Humic Acid Following Chlorination in the Rat. |
Author |
Condie, L. W. ;
Laurie, R. D. ;
Bercz, J. P. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/399; |
Stock Number |
PB86-201498 |
Additional Subjects |
Toxicology ;
Humic acid ;
Chlorination ;
Rats ;
Laboratory animals ;
Bioassay ;
Dosage ;
Reprints ;
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-201498 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
13p |
Abstract |
A subchronic 90-day study was conducted with chlorinated and non-chlorinated humic acids with male Sprague-Dawley rats. Body weight gain, terminal organ and body weights, food and fluid consumption, clinical chemistries, hematological parameters, and urinalyses were determined for all animals. Selected organs were examined microscopially. Significant findings were confined to those rats given the high dose of chlorinated humic acid (1.0 g/L total organic carbon). The terminal body weight and average weekly body weight gain were significantly lower (p < 0.05) in the high dose group as compared to the distilled water control group. The difference can be partially explained by a 16% lower daily fluid consumption. The average weight of the kidneys was significantly higher in the high chlorinated humic group as compared to controls. Hematological parameters and clinical chemistry values were normal in all treatment groups. The most significant finding was the increased incidence and severity of hematuria in the high dose chlorinated humic acid group. |
Supplementary Notes |
Pub. in Jnl. of Toxicology and Environmental Health, v15 n2 p305-314 Feb 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Subchronic Toxicology of Humic Acid Following Chlorination in the Rat. |
PUB Date Free Form |
1985 |
Category Codes |
6T; 57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
621322905 |
Origin |
NTIS |
Type |
CAT |