Main Title |
Recommended Guideline for Acute Oral Toxicity Testing in Rodents. |
CORP Author |
Interagency Regulatory Liaison Group, Washington, DC. |
Year Published |
1981 |
Stock Number |
PB82-119504 |
Additional Subjects |
Toxicology ;
Bioassay ;
Guidelines ;
Ingestion(Biology) ;
Rodents ;
Lethal dosage ;
Mortality ;
LD 50 ;
Toxic substances
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB82-119504 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
14p |
Abstract |
This guideline is designed for use in acute ingestion tests using rodents, but is adaptable to other species. Although several accepted methods for determining LD50 values have been developed, many important determinants of toxicity are not represented either by these values or slopes of dose-response curves for lethality. These determinants are integral to an evaluation of acute toxicity and should be observed during the course of an acute toxicity study. Site and mechanism of action, early or delayed death, and recovery rate may be better indices of toxicity and hazard than LD50 values per se. Morbidity and/or pathogenesis may have more toxicological significance than mortality. |
PUB Date Free Form |
Jan 81 |
Category Codes |
6T; 6E; 57Y; 57O |
NTIS Prices |
PC A02/MF A01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323806967 |
Origin |
NTIS |
Type |
CAT |