Main Title |
Mouse Teratogen Dinocap Has Lower A/D Ratios and Is Not Teratogenic in the Rat and Hamster (Journal Version). |
Author |
Rogers, J. M. ;
Barbee, B. ;
Burkhead, L. M. ;
Rushin, E. A. ;
Kavlock, R. J. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Publisher |
1988 |
Year Published |
1988 |
Report Number |
EPA/600/J-88/153; |
Stock Number |
PB89-110498 |
Additional Subjects |
Environmental surveys ;
Genetics ;
Fungicides ;
Mice ;
Laboratory animals ;
Hamsters ;
Rats ;
Toxicity ;
Dosage ;
Dinocap ;
Teratogens ;
Mildew
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB89-110498 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
10p |
Abstract |
The fungicide dinocap is currently used in the control of powdery mildew. The authors have reported that dinocap is teratogenic in the CD-1 mouse, causing cleft palate, otolith defects, and fetal weight deficits well below maternotoxic dose levels. In the study the maternal and fetal toxicity of dinocap was determined in the Sprague-Dawley rat and Syrian golden hamster, and Adult-to-Developmental (A/D) toxicity ratios were calculated and compared to the previously established A/D ratio of dinocap in the mouse. The A/D ratios for dinocap in the rat and hamster are similar, and are approximately one. These previous studies have demonstrated that dinocap is teratogenic in the mouse, with an A/D ratio in the range of 8-16 in the species. The basis for the species-specific teratogenicity and inconsistent A/D ratio of dinocap is unknown. |
Supplementary Notes |
Pub. in Teratology, v37 p553-559 1988. |
NTIS Title Notes |
Journal article. |
Category Codes |
57F; 57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
836522809 |
Origin |
NTIS |
Type |
CAT |