Main Title |
Yohimbine Attenuates the Delayed Lethality Induced in Mice by Amitraz, a Formamidine Pesticide. |
Author |
Moser, V. C. ;
MacPhail, R. C. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1985 |
Report Number |
EPA/600/J-85/306; |
Stock Number |
PB86-162310 |
Additional Subjects |
Pesticides ;
Lethal dosage ;
Mice ;
Laboratory animals ;
Reprints ;
Yohimbine ;
Amitraz
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB86-162310 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
8p |
Abstract |
The authors have found that a single dose of amitraz, a formamidine pesticide, produces death in mice which begins about two days after dosing and continues for up to 5 more days. To further examine the phenomenon, adult albino mice of both sexes were treated with either yohimbine (10 mg/kg, i.p.) or deionized water (6 ml/kg, i.p.), immediately before an injection of amitraz (600 mg/kg, i.p.) and twice daily thereafter for eight days. Male mice treated with water were more susceptible than water-treated females to the lethal effects of amitraz. In addition, yohimbine treatment significantly decreased the number of deaths in both sexes. These data suggest that an 2-adrenergic mechanism is involved in the delayed lethality produced by amitraz. |
Supplementary Notes |
Pub. in Toxicology Letters 28, n2/3 p99-104 Nov 85. |
NTIS Title Notes |
Journal article. |
Title Annotations |
Reprint: Yohimbine Attenuates the Delayed Lethality Induced in Mice by Amitraz, a Formamidine Pesticide. |
PUB Date Free Form |
1985 |
Category Codes |
6T; 57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
611417724 |
Origin |
NTIS |
Type |
CAT |