Main Title |
Inhalation Teratology Studies of Captan and Folpet in Mice. |
Author |
Courtney, K. D. ;
Andrews, J. E. ;
Stevens, J. T. ;
Farmer, J. D. ;
|
CORP Author |
Health Effects Research Lab., Research Triangle Park, NC. |
Year Published |
1983 |
Report Number |
EPA-600/1-83-017; |
Stock Number |
PB84-128099 |
Additional Subjects |
Toxicology ;
Pesticides ;
Fungicides ;
Mice ;
Laboratory animals ;
Exposure ;
Chlorine organic compounds ;
Dosage ;
Concentration(Composition) ;
Nitrogen organic compounds ;
Folpet ;
Captan ;
Cyclohexane dicarboximide/N-((trichloromethyl)thio) ;
Teratogenesis ;
Phthalimide/N-((trichloromethyl)-thio)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB84-128099 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
20p |
Abstract |
Timed pregnant CD-1 mice were exposed to captan or folpet by the intragastric, subcutaneous or inhalation route. A dose of 100 mg/kg/day of captan or folpet was administered subcutaneously or intragastrically from day 6-15 of gestation. The dose levels for the inhalation route were averaged from daily exposure levels determined by monitoring the chambers. The inhalation route provided daily average concentrations approximating 491 mg/hr/cu. m. for captan and 624 mg/hr/cu. m. for folpet, four hr/day from the 6th to the 13th day of gestation. The particle size was less than 5 micrometers. There was approximately 10% material mortality with both captan and folpet by the inhalation route, while no mortality was seen by the other two routes. The only fetal toxicity noted was a reduction in fetal body weight in the group administered captan subcutaneously. Neither captan or folpet were teratogenic in CD-1 mice exposed by the subcutaneous, oral or inhalation routes. |
PUB Date Free Form |
Dec 83 |
Category Codes |
6T; 6F; 57Y; 68E |
NTIS Prices |
PC A02/MF A01 |
Primary Description |
600/11 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
406248195 |
Origin |
NTIS |
Type |
CAT |