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OLS Field Name OLS Field Data
Main Title Chemical Separation and In situ Mutagenicity Testing.
Author Moeller, M. ; Bjoerseth, A. ; Houk, V. S. ;
CORP Author Health Effects Research Lab., Research Triangle Park, NC. ;Central Inst. for Industrial Research, Oslo (Norway).
Year Published 1985
Report Number EPA/600/D-85/236;
Stock Number PB87-167813
Additional Subjects Chemical analysis ; Carcinogens ; Mutagens ; Toxicity ; Separation ; Tests ; Mixtures ; Chromatographic analysis ; Salmonella ; Detection ; Bioassay ; Industrial wastes ; Waste water ; Textiles ; Paper industry ; Distillation ; Reprints ;
Library Call Number Additional Info Location Last
NTIS  PB87-167813 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/21/1988
Collation 25p
Abstract The traditional way to characterize a complex sample has been by chemical analysis to identify the individual components. However, unknown or overlooked mutagens or carcinogens may remain undetected by this method. In recent years a combination of chemical analysis and mutagenicity testing has been applied successfully to samples to provide a more complete assessment of mutagens in complex mixtures. The authors recently reported a new technique whereby complex samples were separated on thin-layer chromatography plates, and their mutagenic effect was registered directly on the developed plate by the Salmonella mutagenicity assay. This combined fractionation/bioassay scheme offers several advantages. Components of complex samples can be separated by one- or two- dimensional chromatography prior to exposure to the bacteria. By using the TLC plates, toxic compounds or components exhibiting synergistic/antagonistic effects may be separated from the mutagens and detected independently.
Supplementary Notes Pub. in Mutagenicity Testing in Environmental Pollution Control, p47-68 1985. Prepared in cooperation with Central Inst. for Industrial Research, Oslo (Norway).
NTIS Title Notes Journal article.
Title Annotations Reprint: Chemical Separation and In situ Mutagenicity Testing.
PUB Date Free Form c1985
Category Codes 57E; 57B; 99A
NTIS Prices PC A02/MF A01
Primary Description 600/11
Document Type NT
Cataloging Source NTIS/MT
Control Number 716916825
Origin NTIS
Type CAT