||Dermal Absorption of Hexachlorophane in Infants.
Curley, August ;
Hawk, Robert E. ;
Kimbrough, Renate D. ;
Nathenson, Gerald ;
Finberg., Laurence ;
||Environmental Protection Agency, Chamblee, Ga. Office of Pesticides Programs.
Chlorine organic compounds ;
Experimental data ;
Laboratory animals ;
Physiological effects ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Hexachlorophane is widely used as an antibacterial agent. It has been reported that repeated high oral doses of hexachlorophane (25 mg per kg per day) in rats produced paralysis and a pronounced oedema of the white-matter of the central nervous system. To see whether hexachlorophane may be absorbed through the intact infant skin, its concentration in the blood of the umbilical cord of fifty infants and in the blood of the same infants obtained on discharge from hosital was determined by gas chromatography. While in the hospital the infants were washed several times with hexachlorophane solutions to prevent staphylococcal infections. The range of hexachlorophane levels in the umbilical cord was 0.003-0.182 p.p.m. with a mean of 0.022 p.p.m., and for the blood at the time of discharge from the hospital 0.009-0.646 p.p.m., with a mean of 0.109 p.p.m. It is suggested that infants' skin be rinsed after the use of hexachlorophane.
||Pub. in The Lancet, p296-297, 7 Aug 71.
||Included in the report, Journal Articles on Toxicology. Group 8, PB-279 739.
||Reprint: Dermal Absorption of Hexachlorophane in Infants,
|PUB Date Free Form
||6T; 6O; 57Y; 57Q
||(Order as PB-279 739, MF A01)