Main Title |
Brain-Acetylcholinesterase Inhibition in a Marine Teleost during Lethal and Sublethal Exposures to 1,2-Dibromo-2,2-dichloroethyl Dimethyl Phosphate (Naled) in Seawater. |
Author |
Coppage, David L. ;
Matthews., Edward ;
|
CORP Author |
Environmental Protection Agency, Gulf Breeze, Fla. Gulf Breeze Environmental Research Lab. |
Year Published |
1974 |
Report Number |
GULF BREEZE CONTRIB-199; |
Stock Number |
PB-280 834 |
Additional Subjects |
Pesticides ;
Cholinesterase inhibitors ;
Insecticides ;
Toxicology ;
Phosphorus organic compounds ;
Exposure ;
Lethal dosage ;
Bromine organic compounds ;
Chlorine organic compounds ;
Fishes ;
Toxic diseases ;
Bioassay ;
Physiological effects ;
Marine fishes ;
Sublethal dosage ;
Brain ;
Lagodon rhomboides ;
Reprints ;
Naled ;
Toxic substances ;
Teleostes ;
Pinfish ;
Water pollution effects(Animals)
|
Holdings |
Library |
Call Number |
Additional Info |
Location |
Last Modified |
Checkout Status |
NTIS |
PB-280 834 |
Some EPA libraries have a fiche copy filed under the call number shown. |
|
07/26/2022 |
|
Collation |
6p |
Abstract |
To determine if brain-acetylcholinesterase (AChE) inhibition in a marine teleost Lagodon rhomboides (pinfish) by an organophosphate pesticide (naled) is specific enough to diagnose anticholinesterase poisoning, brain-AChE inhibition by sublethal exposure in seawater was compared to brain-AChE inhigition caused by lethal exposure. A sublethal exposure did not inhibit brain-AChE as much as lethal exposure in periods of 24, 48, and 72 hr. Consistent levels of inhibition (84-89% inhibition) occurred when 40-60% of an exposed populaion of pinfish was killed. This correlation of brain-AChE inhibition with exposure and death in a fish population shows that brain-AChE measurements are of value in diagnosing anticholinesterase poisoning in a marine fish. |
Supplementary Notes |
Pub. in Toxicology and Applied Pharmacology 31, p128-133 1975. |
Availability Notes |
Included in the report, Journal Articles on Toxicology, Group 16, PB-280 830. |
Title Annotations |
Reprint: Brain-Acetylcholinesterase Inhibition in a Marine Teleost during Lethal and Sublethal Exposures to 1,2-Dibromo-2,2-dichloroethyl Dimethyl Phosphate (Naled) in Seawater, |
PUB Date Free Form |
27 Mar 74 |
Category Codes |
6T; 8A; 57Y; 68E; 47D; 68D |
NTIS Prices |
(Order as PB-280 830, MF A01) |
Primary Description |
500/01 |
Document Type |
NT |
Cataloging Source |
NTIS/MT |
Control Number |
323740911 |
Origin |
NTIS |
Type |
CAT |