||Teratology Studies with 2,4,5-Trichlorophenoxyacetic Acid and 2,3,7,8-Tetrachlorodibenzo-P-dioxin.
Courtney, K. Diane ;
Moore., John A. ;
||National Institute of Environmental Health Sciences, Research Triangle Park, N.C.
Laboratory animals ;
Congenital abnormalities ;
Cleft palate ;
Chlorine organic compounds ;
Toxic substances ;
Acetic acid/dichlorophenoxy ;
D 2-4 herbicide
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were teratogenic in the CD-1, DBA/2J, and C57B1/6J strains of mice. Both compounds produced cleft palates and kidney malformations. When these compounds were administered in combination, the activity was not potentiated at the doses employed. In the CD rat, 2,4,5-T was neither teratogenic nor fetotoxic. However, TCDD produced kidney anomalies. Prenatal administration of 2,4,5-T did not affect the postnatal growth and development of the CD rat.
||Pub. in Toxicology and Applied Pharmacology 20, p396-403 1971.
||Included in the report, Journal Articles on Toxicology. Group 11, PB-280 001.
||Reprint: Teratology Studies with 2,4,5-Trichlorophenoxyacetic Acid and 2,3,7,8-Tetrachlorodibenzo-P-dioxin,
|PUB Date Free Form
||22 Feb 71
||6T; 57Y; 68G; 68E
||(Order as PB-280 001, MF A01)