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OLS Field Name OLS Field Data
Main Title Teratology Studies with 2,4,5-Trichlorophenoxyacetic Acid and 2,3,7,8-Tetrachlorodibenzo-P-dioxin.
Author Courtney, K. Diane ; Moore., John A. ;
CORP Author National Institute of Environmental Health Sciences, Research Triangle Park, N.C.
Year Published 1971
Stock Number PB-280 005
Additional Subjects Pesticides ; Herbicides ; Toxicology ; Mice ; Rats ; Laboratory animals ; Bioassay ; Congenital abnormalities ; Dosage ; Injections(Medicine) ; Pathology ; Kidney ; Cleft palate ; Chlorine organic compounds ; Toxic substances ; Reprints ; Teratology ; Fetuses ; Dioxin/tetrachloro-dibenzo ; Acetic acid/dichlorophenoxy ; D 2-4 herbicide
Library Call Number Additional Info Location Last
NTIS  PB-280 005 Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy. 06/23/1988
Collation 8p
Abstract The herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were teratogenic in the CD-1, DBA/2J, and C57B1/6J strains of mice. Both compounds produced cleft palates and kidney malformations. When these compounds were administered in combination, the activity was not potentiated at the doses employed. In the CD rat, 2,4,5-T was neither teratogenic nor fetotoxic. However, TCDD produced kidney anomalies. Prenatal administration of 2,4,5-T did not affect the postnatal growth and development of the CD rat.
Supplementary Notes Pub. in Toxicology and Applied Pharmacology 20, p396-403 1971.
Availability Notes Included in the report, Journal Articles on Toxicology. Group 11, PB-280 001.
Title Annotations Reprint: Teratology Studies with 2,4,5-Trichlorophenoxyacetic Acid and 2,3,7,8-Tetrachlorodibenzo-P-dioxin,
PUB Date Free Form 22 Feb 71
Category Codes 6T; 57Y; 68G; 68E
NTIS Prices (Order as PB-280 001, MF A01)
Primary Description 500/01
Document Type NT
Cataloging Source NTIS/MT
Control Number 323739371
Origin NTIS
Type CAT