||Physiologically Based Pharmacokinetic Model for 2,3,7,8-Tetrabromodibenzo-p-Dioxin (TBDD) in the Rat: Tissue Distribution and CYP1A Induction.
Kedderis, L. B. ;
Mills, J. J. ;
Andersen, M. E. ;
Birnbaum, L. S. ;
||Health Effects Research Lab., Research Triangle Park, NC. Environmental Toxicology Div. ;North Carolina Univ. at Chapel Hill. Curriculum in Toxicology. ;Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.
Mathematical models ;
Toxic substances ;
Risk assessment ;
Enzyme induction ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||Biologically based models serve as valuable tools for integration of mechanistic pharmacokinetic data by their explicit definition of important determinants of chemical disposition. The objective of the present work was to develop a physiologically based pharmacokinetic model to describe the disposition and enzyme induction properties of 2,3,7,8-tetrabromodibenzo-p-dioxin (TBDD). The TBDD model, which was based on models previously developed for 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), incorporated: ternary interactions between TBDD, the Ah receptor, and specific DNA-binding sites; induction of a TBDD-binding protein specific to the liver; and diffusion-limited tissue uptake. (Copyright (c) 1993 by Academic Press, Inc.)
||Pub. in Toxicology and Applied Pharmacology 121, n1 p87-98 Jul 93. See also PB91-211466 and PB92-150747. Prepared in cooperation with North Carolina Univ. at Chapel Hill. Curriculum in Toxicology, and Chemical Industry Inst. of Toxicology, Research Triangle Park, NC.
|NTIS Title Notes
||Reprint: Physiologically Based Pharmacokinetic Model for 2,3,7,8-Tetrabromodibenzo-p-Dioxin (TBDD) in the Rat: Tissue Distribution and CYP1A Induction.
||PC A03/MF A01