||Final Report on the Evaluation of Four Toxic Chemicals in an 'In vivo/In vitro' Toxicological Screen: Acrylamide, Chlordecone, Cyclophosphamide, and Diethylstilbestrol.
||Health Effects Research Lab., Research Triangle Park, NC.
In vivo analysis ;
In vitro analysis ;
Toxic substances ;
||Most EPA libraries have a fiche copy filed under the call number shown. Check with individual libraries about paper copy.
||An in vivo/in vitro Toxicological Screen (Tox Screen) has been developed for screening large numbers of wastes for biological activity. Emphasis is placed on identifying a wide range of potential toxic responses by employing diverse test methods with toxic endpoints in mutagenesis/carcinogenesis, general toxicology, neurotoxicology, reproductive toxicology, teratology, teratology, and immunotoxicology. Oral administration of waste material is given to rats for 10 consecutive days after which the whole animal, body tissues and fluids are evaluated for toxicity. The Tox Screen is being validated to ensure that the protocol will be capable of detecting biological activity and to identify those assays which most readily detect toxicity. The most accurate and sensitive assays would be used as a Prescreen for the entire protocol. Results of the validation study with 4 toxic chemicals are included. Acrylamide produced its greatest effects in the neurotox assays and in mutagenesis.
|PUB Date Free Form
||6T; 6E; 57Y; 57O
||PC A05/MF A01